Notice biographique Repères biographiques communs. Nom : VIVIEN Prénom : DENIS Section : 69 Corps : PR Grade : professeur classe exceptionnelle 2

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1 Notice biographique Repères biographiques communs Nom : VIVIEN Prénom : DENIS Section : 69 Corps : PR Grade : professeur classe exceptionnelle 2 Equipe de recherche INSEMR UMR-S U919 Ecole doctorale Paris XI, Orsay Directeur de thèse Jean Pierre PUJOL Etablissement du doctorat Université Paris XI Garant de l'habilitation à diriger les recherches Université de Caen Publications caractéristiques des domaines de spécialités -Nicole O, Docagne F, Ali C, Margaill I, Carmeliet P, MacKenzie ET, Vivien D*, Buisson A*. The proteolytic activity of tissueplasminogen activator enhances NMDA receptor-mediated signaling. Nat Med. 2001, 7: Benchenane K, Berezowski V, Ali C, Lopez-Atalaya J, Fernandez-Monreal M, Brillault J, Chuquet J, Bu G, Nouvelot A, MacKenzie ET, Cecchelli R, Touzani O, Vivien D. Tissue type plasminogen activator crosses the intact blood brain barrier by LDL-related receptor protein-mediated transcytosis. Circulation 2005;111: Roussel BD, Macrez R, Jullienne A, Agin V, Maubert E, Dauphinot L, Potier MC, Plawinski L, Castel H, Hommet Y, Munuera J, Montaner J, Yepes M, Ali C*, Vivien D*. Age and albumin D site-binding protein control tissue plasminogen activator levels: neurotoxic impact. Brain. 2009;132: Cassé F, Bardou I, Danglot L, Briens A, Montagne A, Parcq J, Alahari A, Galli T, Vivien D*, Docagne F*. Glutamate controls tpa recycling by astrocytes, which in turn influences glutamatergic signals. J Neurosci. 2012; 32: Le Behot A, Gauberti M, Martinez De Lizarrondo S, Montagne A, Lemarchand E, Repesse Y, Guillou S, Denis CV, Maubert E, Orset C, Vivien D. GpIb-VWF blockade restores vessel patency by dissolving platelet aggregates formed under very high shear rate in mice. Blood May 22;123(21): Titres et diplômes :

2 1992PhD, Université d'orsay, Paris XI Cell Mol. Biol. Title: TGF-beta and chondrocyte proliferation 1997 HDR, Université de Caen, Neurosciences Title: TGF-beta and neuroprotection 2009 Membre SENIOR Institut Universitaire de France Autres diplômes : Activités professionnelles dans le Supérieur : Research fellow at the laboratory of Dr Joan Massagué, New York, USA, Sloan Kettering Cancer Center, Howard Hughes Institute Associate Professor in Molecular Biology, University of Caen Professor in Neurosciences, University of Caen Vice-director of UMR 6185 CNRS / Université de Caen "Neurodégénérescence et Stratégies Thérapeutiques", GIP Cyceron Head of Inserm-Avenir "tpa in the working brain", GIP Cyceron, Caen Director of Inserm UMR-S U919 "serine proteases and Pathophysiology of the neurovascular Unit. Renew in Coordinator of an FRM team Fondation pour la Recherche Medical ( ) entitled immunotherapy for stroke Autres activités professionnelles :

3 Teachings: Co-coordinator and creator of a MST "Acquisition et Traitementde l Image en Biologie" (L3), Caen Coordinator of a professional master degree "Imagerie de la Santé" Co-coordinator of a professional/research master degree du master «Neurosciences et Imagerie de la Santé» Scientific advisory boards/networks coordination: Coordinator of the European Network of Excellence "diagnostic molecular imaging", DIMI, 6th PCRDT Group leader and workpackage coordinator within the framework of the European Network Eurostroke (Arise + Eustroke) FP Coordinator of the European FP7 ERANET-Neuron network, Protea Co-coordinator European FP7, Marie Curie International Training Network NeuroInflammation. Partner of the FP7 «Mutlipart» network Scientific advisor for pharmas: PAION (Aachen, Germany) and Lundbeck (Copenhaguen, Sweden) Scientific advisor for a Start-up "Theraprot" created by a former PhD student and hosted in my lab; President of the Scientific council of the IBISA platform «Experimental Stroke Research Platform», created in 2013 by my team, Caen; Member of committees: section 69 (neurosciences) of the Conseil National des Universités (CNU)

4 section 1 "neurosciences, neurologie et neuro-psychiatrie" INSERM, CSS President of section 69 (neurosciences) of Conseil National des Universités (CNU) 2013-Vice-President of the Committee for Biomedical Research and Public Health of the Caen Hospital; Scientific advisor for Neurosciences at the Caen University ; Scientfic council of the «fondation Thèrèse et René Planiol» Informations complémentaires : Expert: National : comité national pour l'évaluation de la recherche et de pédagogie universitaire (AERES), Agence française de recherche (ANR), agence française de sécurité sanitaire des produits de santé /agence nationale de sécurité du médicament et des produits de santé (AFSSAPS/ANSM) and many foundations (FRC, FRM, ARC...). International: Medical Research Council (UK), Institut National de la Santé (EU), Ministry of Research from Spain, Cahta Catalonia, Maraton TV3, Israel, Poland, Australia, China... - Reviewer for many international journals (Nat. Med., Nat Rev Neurosci., J. Clin. Invest., J. Neurosci...). - Member of editorial boards Cerebrovasc. Dis., Current Alzh. Dis., Int. J. Stroke. - Member of organizing committees: Journées de la Société française neuro-vasculaire (2011 et 2012); European Stroke Conferences (2011 Hambourg, 2012 Lisbonne et 2013 Londres), International Society of Fibrinolysis and Proteolysis (Brighton, 2012, Marseille, 2014). Member of the Administration Council of "France AVC Normandie ". AWARDS

5 Vivien D., 1st price of Medical Innovation from Matmut - Fondation de l Avenir, for his work on a novel strategy of immunotherapy for stroke, Vivien D., Parcq J., 2nd price for innovation, FRM 2011 Elected permanent member of the council of the International Society of Fibrinolysis and Proteolysis, 2012, Brighton, UK. Inserm U919 Vivien D., Price of the Fondation Schlumberger 2012 for the project «Cérébro»