Hébergement sur le campus et coût Institut Pasteur de Shanghai

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1 Institut Pasteur, Direction internationale, E. Coëffier BOURSES FONDATION PIERRE LEDOUX JEUNESSE INTERNATIONALE 33ème APPEL D OFFRE RESEAU INTERNATIONAL DES INSTITUTS PASTEUR Propositions de Stages Institut N Labo/Service 1 Pathogenic Fungal Infection & Host Immunity Changbin CHEN cbchen@ips.ac.cn Genetic screen for Candida albican mutants defective in gastrointestinal tract colonization 2016,5 One intern, RMB800 per month 2 Unit of Innate Immunity Guangxun MENG gxmeng@ips.ac.cn Mechanism of inflammasome activation We have identified a number of new factors that are likely involved in the activation process of the NLRP3 inflammasome, validation of these factors will be topics for an internship student. July, Previous Training with molecular biology, biochemistry, cell biology is helpful. July 1, 2016 Rent RMB/month 3 Arbovirus interspecies transmission unit Dimitri LAVILLETTE dlaville@ips.ac.cn By studying both infections in mammals and insects in vitro and/or in vivo, our global project wants to unveil the viral and/or host factors responsible for pathogenicity, resistance and interspecies transmission. We are using different 9 Candidate must have a Master 1 of biology (virology knowledge). Intership will be for a Master 2 Between Oct 2016 and February 2017 Depend on availability (to be evaluated with administration) Page 1 sur 5

2 arbovirus models like Dengue, Zika and Chikungunya viruses diploma intership. 4 Molecular immunology Bin LI binli@sibs.ac.cn Post-transcription modification of FOXP3 in Treg cells or RORγt in Th17 cells The balance of Treg cells and Th17 cells are important in several kinds of autoimmune diseases. The posttranscription modification, such as ubiquitination, phosphorylation could regulate the protein level or function of master transcription regulates in these two T cell subsets. We are interested in this research files and welcome internship to work together August, 2016 Familiar with primary T cell culture and biochemistry. April 1, 2016 Need to rent department near the institute 5 Infection and Immunology Hong TANG htang@ips.ac.cn HCV persistent infection has been linked to malignant immunopathological progression in liver cirrhosis. The underlying mechanisms are still elusive. The desired internship is expect to study the mechanism of impaired immune homeostasis in HCV persistent infection. In particular, the duration will mainly deal with the formation of tertiary lymphoid organ (TLO) during the acute infection of HCV in our humanized mice model, and try to determine the structure and function of of TLO, and the lymphogenesis of TLO in persistent infection August, 2016 familiar with immunology and virology 01/06/2016 Need to rent department near the institute 6 G4-Immunology Unit Tineke Cantaert tcantaert@pasteurkh.org Protective or disease enhancing? The dual role of B cells in dengue viral infection 6 Background in life sciences eg Biochemistry, Molecular Biology, Immunology Whenever possible 2

3 7 Unité de Virologie Duong Veasna PREDICT 2: Surveillance for emerging zoonotic disease threats and behavioral risk characterization in high-risk communities in Cambodia This research aims to 1) detect and characterize new and known viruses of epidemic and pandemic potential in high-risk communities and patients admitted to hospitals; 2) identify biological, behavioral, and ecological factors influencing the risk of viral spillover, amplification, and spread; and 3) determine potential targets for intervention based on high-risk human behaviors and practices that amplify disease transmission in hotspots for viral evolution, spillover, amplification, and spread. 3-6 mois Master 2 ou pharmacien ou médecin ou vétérinaire Willing to participate in field work in remote areas, knowledge in with molecular biology techniques (PCRs, sequencing, ), 8 Unité de Virologie Philippe Dussart pdussart@pasteurkh.org Study of immunity against 1960s Chikungunya strains among Cambodian people with immunity acquired in 2012 A recent study from Institut Pasteur du teams has documented a long-lasting immune protection after Chikungunya emergence in a rural community in April Being aged above 40 was a significant protective factor for CHIKV infection, reflecting immune protection collectively acquired while Chikungunya circulated in Cambodia in the 1960s and 1970s prior to the beginning of the Khmer Rouge regime in These data support the persistence of CHIKV antibodies over a period of 40 years. These findings, need to be further explored in the 6 9 mois Master 2 ou pharmacien ou médecin ou vétérinaire Knowledge in serological test (ELISA, HI) and cell culture and seroneutralizatio n assay. October

4 Montevideo 9 Epidémiologie & 10 Epidémiologie & 11 Epidémiologie & Arnaud Tarantola atarantola@pasteurkh.org Laurence Borand lborand@pasteurkh.org Laurence Borand lborand@pasteurkh.org 12 SANYAL Lab Sumana Sanyal 13 SANYAL Lab Sumana Sanyal 14 SANYAL Lab Sumana Sanyal 15 Unité des Mycobactéries 16 Unité des Mycobactéries 17 Unité Entomologie Médicale 18 BioMolecular Simulations Voahangy Rasolofo, vrasolof@pasteur.mg Niaina Rakotosamimanana niaina@pasteur.mg Sébastien Boyer seboyer@pasteur.mg Matias Machado, mmachado@pasteur.e du.uy laboratory. Facteurs associés aux infections asymptomatiques par le virus Chikungunya. Mise en place de l étude PERILIC sur la coqueluche au Appui à la conduite / formation continue des moniteurs de l étude BIRDY Virus-host interaction: Characterization of host factors involved in virus infections ons Virus-host interaction: Targeting deubiquitylases as therapeutic strategies against viral infections Virus-host interaction: Regulation of immune signaling by deubiquitylases Performance du test TB-LAMP pour le diagnostic de la tuberculose Etude in silico de la plasticité du génome de M. tuberculosis Relation entre vecteurs de paludisme et nombre de cas de paludisme Searching for novel drug targets against Dengue and Zika by molecular modeling and dynamic simulation of 5-6 mois Master épidémiologie 6 mois Interne en Pharmacie ou en (recherché Clinique) 6 mois Interne en pédiatrie 6 mois Master ou PhD Epidémiologiestatistique ou biostatistique 2-6 mois Master en bioinformatique 6 mois Master Santé Public 3 Master degree in Theoretical Chemistry, Mai- Oui, Mai- Oui, Mai- Oui, Juillet 2016 June/2016 No 4

5 full viral particles Bioinformatics or Biophysics. Basic in molecular dynamics simulations and scripting 5