UNITÉ DE RECHERCHE Centre de Recherche en Oncologie Biologique et Oncopharmacologie

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1 UNITÉ DE RECHERCHE Centre de Recherche en Oncologie Biologique et Oncopharmacologie DIRECTEUR : LOMBARDO Dominique ADRESSE : Facultés de Médecine et Pharmacie Site Timone TELEPHONE : /02 COURRIEL : dominique.lombardo@univ-amu.fr ECOLE DOCTORALE : Sciences de la Vie et de la Santé (ED 062) RATTACHEMENTS : AMU INSERM POLES HOSPITALIERS : 3 - Imagerie Médicale (Intersites) 5 - Anapath-Digestif-Onco-Uro-Endocrinologie (Nord) 6 - Neurosciences Cliniques (Intersites) 13 - Pédiatrie Médico-Chirurgicale (Timone Enfants) 16 - Cardio-Vasculaire-Thoracique (Intersites) 18 - Biologie (Intersites) 26 - MINC SMC (Intersites) 28 - Oncologie Spec.Médicales Chirurgicales (Intersites) 24 - Pharmacie (Intersites) DISCIPLINES D APPARTENANCES : DS 5 - Biologie, médecine, santé SPECIALITÉS : Oncologie/Immunologie/Neurooncologie/Pharmacologie GESTIONNAIRES UNITÉ : Laurent NOE EFFECTIFS Enseignants-Chercheurs : 49 Chercheurs EPST : 4 Autres Chercheurs : 6 IATOS/ITA : 39 Autres IATOS/ITA : 4 Doctorants : 25 1/23

2 PERSONNELS IMPLIQUÉS DANS LA RECHERCHE ALCARAZ Sonia ADT AMU ALLEGRO Diane ASI AMU ANDRE Frédéric ANDRE Marc TCH INSERM ANDRE Nicolas MCU-PH BAEZA Nathalie IGE AMU BARBIER Pascale BARBOLOSI Dominique PU BAREA Dolores TCH AMU BARLESI Fabrice BASTIDE Cyrille BASTONERO Sonia IE AMU BELOROBI Sadia BENAY Stephan BENYAHIA Zohra BERAUD Evelyne BERGES Raphael POST BERNARD Jean-Paul BERTHOIS Yolande CR INSERM BONIER Rénaté AJT INSERM BOUDOURESQUE Françoise BOURGAREL-REY Véronique BOUVET Sandrine ADA AMU BOUVIER-LABIT Corinne MCU-PH BRAGUER Diane BREUZARD Gilles BRUN Nadia ADT AMU CAMMILLERI Serge MCU-PH CAPRIOLO Guy ADT AMU CARLIER Anne-Sophie ADT AMU CDD CARMONA Sylvie TCH AMU CARRE Manon CAYOL Mylène ADT AMU CHACON Christine ASI AMU CHINOT Olivier CICCOLINI Joseph -PA COLIGNON Aurélie COLIN Carole IGR AMU COLOMB Coline CONTE Philippe AJT INSERM CORREARD Florian CRENON Isabelle DAHAN Laetitia PH DAIZE Caroline IGE AMU DANIEL Laurent DARDAR Zoubeir DELFINO Christine IGR AMU DENICOLAI Emilie DEVRED François DUSSAULT Nadège ASI AMU DUSSERT Christophe CR INSERM EL BATTARI Assou PU ESTEVE Marie-Anne MCU-PH DOUILLARD Soazig IE AMU FAIVRE Christian FANCIULLINO Raphaelle MCU-PH FIGARELLA-BRANGER Dominique GAGNA Véronique ADT AMU GARROUSTE Françoise GAUDY Caroline MCU-PH GAUTHIER Géraldine GERMAIN Sébastien TCH AMU /23

3 GEROLAMI René GIACOMETTI Sarah TCN AMU GROB Jean-Jacques HUYNH Thanh Khoa HONORE Stéphane MCU-PH ILIADIS Athanassios PU INTAGLIATA Dominique TCH AMU JIGUET-JIGLAIRE Carine POST KOVACIC Hervé PU LACARELLE Bruno LAFITTE Daniel IGR AMU LEGRAND Marion LELOUP Ludovic LEMOINE Lenaig ITA CT C contractuel AMU LOMBARDO Dominique DR INSERM LUIS José PU MAROUANI Hafedh MARTINEZ Emmanuelle MARVALDI Jacques PU MAS Eric CR INSERM MATHIEU Sylvie IE INSERM McKAY Nathalie TCN contractuel METELLUS Philippe MCU-PH MERCURIO Sandy MOHAMED Echata ADT AMU MONJANEL-MOUTERDE Suzanne MONTERO Marie-Pierre ADT AMU MORANDO Philippe TCH AMU MOUSSLIM Mohamed AIT BELKACEM Rima E NDYAYE Sega POST NOE Laurent IGE AMU NOUAR Roqya OUAFIK L'Houcine OUAISSI Mehdi MCU-PH PADOVANI Laetitia PAGANO Alessandra PARAT Fabrice TCH AMU PELLEGRINO Emilie PEYROT Vincent PU PIRISI Victor TCH INSERM POMMIER Gilbert MCU-PH PREVOT Charles IR CNRS RICHARD Marie Aleth RIGOT Véronique ROVINI Amandine SALAS Sébastien PH SASTRE Bernard SAVRY Amandine SBARRA Véronique AI INSERM SCHEMBRI Thérèse IGE AMU SEBBAN Sylvie TCN-CDD INSERM SEITZ Jean-François SELLANI Lina SERDJEBI Cindy SIGAUD Romain Master 2 R SILVY Françoise TCH INSERM SIRET Carole IGE AMU/ SOLAS-CHESNEAU Caroline MCU-PH TAYA Sarah TCH INSERM TERCIOLO Chloé THUAUT Sylvie TIJERAS Guylaine ADT AMU TOUNSI Asma VILLARD Claude IE CNRS /23

4 EQUIPES DE RECHERCHE et THEMATIQUES EQUIPE : E1 - Communications microtubules-mitochondries : implication en oncopharmacologie RESPONSABLE : BRAGUER Diane THEMATIQUE : Dialogue microtubules mitochondries et conséquences fonctionnelles. Dépendance à la chimiothérapie et perspectives thérapeutiques EQUIPE : E2 - Micro-environnement Redox, cytosquelette et progression tumorale RESPONSABLE : KOVACIC Hervé/PEYROT Vincent THEMATIQUE : Nox1, progression et migration tumorale. Potentialité thérapeutique et pronostique de la modulation redox en cancérologie EQUIPE : E3 - Progression tumorale et immunothérapie expérimentale RESPONSABLE : LOMBARDO Dominique BERNARD Jean-Paul THEMATIQUE : Immunothérapie expérimentale des adénocarcinomes pancréatiques. Cancer et thrombose. Molécules d'adhésion et carcinogénèse pancréatique EQUIPE : E4 - Angiogenèse, invasivité et micro-environnement tumoral RESPONSABLE : OUAFIK L'Houcine/FIGARELLA-BRANGER Dominique THEMATIQUE : Propriétés intrinsèques et micro-environnement dans le mode de croissance des glioblastomes. Rôle et mécanismes d'action de l'adrénoméduline dans la progression tumorale EQUIPE : SC - Service Commun RESPONSABLE : Laurent NOE Plateforme Pharmacologie (AP-HM, Accréditation COFRAC) RESPONSABLE : LACARELLE Bruno Plateforme Protéomique et Innovation Technologique Timone : PIT2 (labellisation IBISa MaP) RESPONSABLE : LAFITTE Daniel Plateforme Laboratoire de transfert (AP-HM, Accréditation COFRAC) RESPONSABLE : L H OUAFIK. Plateforme Ressources Biologique Tumorothèque (AP-HM, Certification ISO 9001) RESPONSABLE : D. FIGARELLA-BRANGER Plateau Tri cellulaire RESPONSABLE : PREVOT Charles Plateau Imagerie confocale et intravitale RESPONSABLE : BASTONERO Sonia PERSONNELS PAR EQUIPE DE RECHERCHE EQUIPE : E1 - Communications microtubules-mitochondries : implication en oncopharmacologie RESPONSABLE : BRAGUER Diane THEMATIQUE : Dialogue microtubules mitochondries et conséquences fonctionnelles. Dépendance à la chimiothérapie et perspectives thérapeutiques ANDRE Nicolas BERGES Raphael BOURGAREL-REY Véronique BRAGUER Diane CARLIER Anne-Sophie CARRE Manon CHACON Christine CORREARD Florian ESTEVE Marie-Anne GAUTHIER Géraldine HONORE Stéphane LEGRAND Marion MCU-PH POST- ADT AMU CDD ASI AMU MCU-PH MCU-PH 4/23

5 McKAY Nathalie MONTERO Marie-Pierre ROVINI Amandine SAVRY Amandine TAYA Sarah TCN CDD ADT AMU TCH INSERM EQUIPE : E2 - Micro-environnement Redox, cytosquelette et progression tumorale RESPONSABLE : KOVACIC Hervé/PEYROT Vincent THEMATIQUE : Nox1, progression et migration tumorale. Potentialité thérapeutique et pronostique de la modulation redox en cancérologie ALLEGRO Diane ANDRE Marc BARBIER Pascale BOUVET Sandrine BREUZARD Gilles BRUN Nadia DAHAN Laetitia DEVRED François DOUILLARD Soazig GARROUSTE Françoise KOVACIC Hervé LELOUP Ludovic LUIS José MONJANEL-MOUTERDE Suzanne MOUSSLIM Mohamed NOUAR Roqya PAGANO Alessandra PARAT Fabrice PEYROT Vincent POMMIER Gilbert SEITZ Jean-François SELLANI Lina THUAUT Sylvie ASI AMU TCH INSERM ADA AMU ADT AMU PH IE AMU PU PU TCH AMU PU MCU-PH EQUIPE : E3 - Progression tumorale et immunothérapie expérimentale RESPONSABLE : LOMBARDO Dominique BERNARD Jean-Paul THEMATIQUE : Immunothérapie expérimentale des adénocarcinomes pancréatiques. Cancer et thrombose. Molécules d'adhésion et carcinogénèse pancréatique ANDRE Frédéric BELOROBI Sadia BERAUD Evelyne BERNARD Jean-Paul CAMMELIRI Serge CARMONA Sylvie COLIGNON Aurélie CRENON Isabelle GEROLAMI René GERMAIN Sébastien LOMBARDO Dominique MARTINEZ Emmanuelle MARVALDI Jacques MAS Eric OUAISSI Mehdi PELLEGRINO Emilie RIGOT Véronique SASTRE Bernard SBARRA Véronique SEBBAN Sylvie SILVY Françoise SIRET Carole TERCIOLO Chloé MCU-PH TCH AMU TCH AMU DR INSERM PU CR INSERM MCU-PH AI INSERM TCN-CDD INSERM TCH INSERM IGE AMU/ 5/23

6 EQUIPE : E4 - Angiogenèse, invasivité et micro-environnement tumoral RESPONSABLE : OUAFIK L'Houcine/FIGARELLA-BRANGER Dominique THEMATIQUE : Propriétés intrinsèques et micro-environnement dans le mode de croissance des glioblastomes. Rôle et mécanismes d'action de l'adrénoméduline dans la progression tumorale BAEZA Nathalie BAREA Dolores BARLESI Fabrice BASTIDE Cyrille BERTHOIS Yolande BENYAHIA Zohra BOUDOURESQUE Françoise BOUVIER-LABIT Corinne CAYOL Mylène CHINOT Olivier COLIN Carole DAIZE Caroline DANIEL Laurent DARDAR Zoubeir DELFINO Christine DENICOLAI Emilie DUSSAULT Nadège DUSSERT Christophe EL BATTARI Assou FIGARELLA-BRANGER Dominique GAGNA Véronique GAUDY Caroline GROB Jean-Jacques HUYNH Thanh Khoa INTAGLIATA Dominique JIGUET-JIGLAIRE Carine LEMOINE Lenaig MATHIEU Sylvie MERCURIO Sandy METELLUS Philippe MORANDO Philippe OUAFIK L'Houcine PADOVANI Laetitia PIRISI Victor RICHARD Marie Aleth SALAS Sébastien SIGAUD Romain TIJERAS Guylaine TOUNSI Asma IGE AMU TCH AMU CR INSERM MCU-PH ADT AMU IGR AMU IGE AMU IGR AMU ASI AMU CR INSERM PU ADT AMU MCU-PH POST- ITA CT C contractuel AMU IE INSERM MCU-PH TCH AMU TCH INSERM PH Master 2 R ADT AMU Plateforme Pharmacologie (AP-HM, Accréditation COFRAC) RESPONSABLE : LACARELLE Bruno BARBOLOSI Dominique BENAY Stephan CICCOLINI Joseph COLOMB Coline FAIVRE Christian FANCIULLINO Raphaelle GIACOMETTI Sarah ILIADIS Athanassios LACARELLE Bruno MAROUANI Hafedh SERDJEBI Cindy SOLAS-CHESNEAU Caroline PU -PA MCU-PH TCN AMU PU MCU-PH 6/23

7 Plateforme Protéomique et Innovation Technologique Timone (PIT2, labellisation IBISa) RESPONSABLE : LAFITTE Daniel AIT BELKACEM Rima LAFITTE Daniel NDYAYE Sega SCHEMBRI Thérèse SELLAMI Lyna VILLARD Claude E IGR AMU POST- IGE AMU E IR CNRS Plateforme Laboratoire de transfert (AP-HM, Accréditation COFRAC) RESPONSABLE : L H OUAFIK. Plateforme Ressources Biologique Tumorothèque (AP-HM, Certification ISO 9001) RESPONSABLE : D. FIGARELLA-BRANGER Plateau Tri cellulaire RESPONSABLE : PREVOT Charles Plateau Imagerie confocale et intravitale RESPONSABLE : BASTONERO Sonia EQUIPE : SC - Service Commun Recherche RESPONSABLE : NOE Laurent ALCARAZ Sonia BONIER Rénaté BOUVET Sandrine CARLIER Anne-Sophie CAPRIOLO Guy CONTE Philippe GAGNA Véronique NOE Laurent MOHAMED Echata SEBBAN Sylvie ADT AMU AJT INSERM ADA AMU ADT AMU CDD ADT AMU AJT INSERM ADT AMU IGE AMU ADT AMU TCN INSERM CDD PUBLICATIONS ANNÉES 2010 et 2011 Equipe 1 1. Ciccolini J, Mercier C, Dahan L, André N.Integrating pharmacogenetics into gemcitabine dosing-- time for a change? Nat Rev Clin Oncol Feb 8;8(7): (2011) 2. Pasquier E, Ciccolini J, Carre M, Giacometti S, Fanciullino R, Pouchy C, Montero MP, Serdjebi C, Kavallaris M, André N.Propranolol potentiates the anti-angiogenic effects and anti-tumor efficacy of chemotherapy agents: implication in breast cancer treatment. Oncotarget Oct;2(10): (2011) 3. Honore S, Braguer D Investigating microtubule dynamic instability using microtubule-targeting agents.. Methods Mol Biol. 2011;777: (2011) 4. Bouwmeester H, Lynch I, Marvin HJ, Dawson KA, Berges M, Braguer D, Byrne HJ, Casey A, Chambers G, Clift MJ, Elia G, Fernandes TF, Fjellsbø LB, Hatto P, Juillerat L, Klein C, Kreyling WG, Nickel C, Riediker M, Stone V.Minimal analytical characterization of engineered nanomaterials needed for hazard assessment in biological matrices. Nanotoxicology Mar;5(1): Bourdeaut F, Lequin D, Brugières L, Reynaud S, Dufour C, Doz F, André N, Stephan JL, Pérel Y, Oberlin O, Orbach D, Bergeron C, Rialland X, Fréneaux P, Ranchere D, Figarella-Branger D, Audry G, Puget S, Evans DG, Pinas JC, Capra V, Mosseri V, Coupier I, Frequent hsnf5/ini1 Germline Mutations in Patients with Rhabdoid Tumor. Ga Clin Cancer Res Jan 1;17(1): (2011) - [Impact factor=6.768] 6. Combes S, Barbier P, Douillard S, McLeer-Florin A, Bourgarel-Rey V, Pierson JT, Fedorov AY, Finet JP, Boutonnat J, Peyrot V. Synthesis and Biological Evaluation of 4-arylcoumarin Analogues of Combretastatins. J Med Chem May 12;54(9): (2011) 7/23

8 7. Fousseyni T, Diawara M, Pasquier E, André N Children treated with metronomic chemotherapy in a low-income country: METRO-MALI-01 J Pediatr Hematol Oncol Jan;33(1): (2011) - [Impact factor=0.794] 8. Rovini A, Savry A, Braguer D, Carré M Microtubule-targeted agents: When mitochondria become essential to chemotherapy. Biochim Biophys Acta Jun;1807(6): (2011) - [Impact factor=4.840] 9. Mercier C, Dahan L, Ouafik L, André N, Ciccolini J. Letter to the editor: pharmacokinetics of gemcitabine in non-small-cell lung cancer patients: impact of the 79A>C cytidine deaminase polymorphism. Eur J Clin Pharmacol Sep;66(9): (2010) - [Impact factor=2.743]. 10. Guilhaumou R, Solas C, Rome A, Giocanti M, Andre N, Lacarelle B. Validation of an electrospray ionization LC/MS/MS method for quantitative analysis of vincristine in human plasma samples. J Chromatogr B Analyt Technol Biomed Life Sci Feb 1;878(3-4): (2010) 11. Ciccolini J, Dahan L, André N, Evrard A, Duluc M, Blesius A, Yang C, Giacometti S, Brunet C, Raynal C, Ortiz A, Frances N, Iliadis A, Duffaud F, Seitz JF, Mercier C. Cytidine deaminase residual activity in serum is a predictive marker of early severe toxicities in adults after gemcitabine-based chemotherapies. J Clin Oncol ; 28: (2010) - [Impact factor=17.793] 12. Ianotto JC, Tempescul A, Eveillard JR, André N, Morel F, Quintin-Roué I, Berthou C Acute dyspnoea and single tracheal localisation of mantle cell lymphoma. J Hematol Oncol Sep 28;3:34 - (2010) - [Impact factor=1.360] 13. André N, Pasquier E, Gentet JC, Kamen BA. Looking at the Seemingly Contradictory Role of Vinblastine in Anaplastic Large-Cell Lymphoma From a Metronomic Perspective. J Clin Oncol Dec 20 - (2010) - [Impact factor=17.793] 14. Andre N, Padovani L, Verschuur A. Metronomic chemotherapy: Back to the future! Drug News Perspect. 2010; 23 : (2010) - [Impact factor=2.305] 15. Sterba J, Pavelka Z, André N, Ventruba J, Skotakova J, V Bajciova V, Bronisova D, Dubska L, Valik D. Second complete remission in a child with relapsed medulloblastoma induced by metronomic chemotherapy and subsequent progression shortly after chemotherapy cessation. Pediatr Blood Cancer 2010; 54: (2010) - [Impact factor=2.134] 16. André N, Pasquier E. Can Drug Driven Dependency and Deprivation Effect be used as a therapeutic tool in patients with tuberculosis? Int J Tuberc Lung Dis Sep;14(9): (2010) - [Impact factor=2.548] 17. Pasquier E, Kavallaris M, André N. Metronomic chemotherapy: new rationale for new directions Nat Rev Clin Oncol Aug;7(8): (2010) - [Impact factor=8.000] 18. André N, Verschuur A, Rossler J, Sterba J. Anti-Angiogenic Therapies for Children with Cancer. Curr Cancer Drug Targets Aug (2010) - [Impact factor=5.177] 19. André N, Pasquier E, Gentet JC, Kamen BA. Looking at the Seemingly Contradictory Role of Vinblastine in Anaplastic Large-Cell Lymphoma From a Metronomic Perspective. J Clin Oncol Dec (2010) - [Impact factor=17.793] 20. Calligaris, D., Verdier-Pinard, P., Devred, F.,Villard, C.,Braguer, D and Lafitte, D Microtubule targeting agents : from biophysics to proteomics. Cell Mol Life Sci ;67: (2010) - [Impact factor=6.090] 21. Bazaa A, Pasquier E, Defilles C, Limam I, Kessentini-Zouari R, Kallech-Ziri O, El Battari A, Braguer D, El Ayeb M, Marrakchi N, Luis J. MVL-PLA2, a snake venom phospholipase A2, inhibits angiogenesis through an increase in microtubule dynamics and disorganization of focal adhesions PLoS One ; 5 :e (2010) - [Impact factor=4.383] 22. Rovini A, Carré M, Bordet T, Pruss R M and Braguer D. Olesoxime prevents microtubule-targeting drug neurotoxicity: selective preservation of EB comets in differentiated neuronal cells. Biochem Pharmacol Sep 15;80(6): (2010) - [Impact factor=4.254] 23. Calligaris D, Villard C, Terras L, Braguer D, Verdier-Pinard P, Lafitte D. MALDI in-source decay of high mass protein isoforms: application to alpha- and beta-tubulin variants. Anal Chem Jul 15;82(14): (2010) - [Impact factor=5.625] Equipe 2 1. Froudarakis ME, Greillier L, Monjanel-Mouterde S, Koutsopoulos A, Devictor-Pierre B, Guilhaumou R, Karpathiou G, Botaitis S, Astoul P Intrapleural administration of lipoplatin in an animal model. Lung Cancer. 2011; 72(1): (2011) 2. Sarray S., Kessentini-Zouari R., Jebali J., Limam I., Bazaa A., Morjen M., Abdelkafi Z., Kallech-Ziri O., Srairi N., Daoued S., Luis J., El Ayeb M & Marrakchi N.:Anti-tumor snake venoms peptides In : Barbier J. et al., eds. Toxins and ion transfert -Meetings on toxinology, SFET Editions. 2011; pp (2011) 3. Kallech-Ziri O, Luis J, Sabatier J-M, El Ayeb M, Marrakchi N, Loret E. Structure-function relationships of KTS disentegrins and the development of anti-angiogenic drugs against cancer. Lett Drug Design Discovery , (2011) 8/23

9 4. Yang CG, Ciccolini J, Blesius A, Dahan L, Bagarry-Liegey D, Brunet C, Varoquaux A, Frances N, Marouani H, Giovanni A, Ferri-Dessens RM, Chefrour M, Favre R, Duffaud F, Seitz JF, Zanaret M, Lacarelle B, Mercier C. DPD-based adaptive dosing of 5-FU in patients with head and neck cancer: impact on treatment efficacy and toxicity. Cancer Chemoth Pharm. 2011; 67(1): (2011) 5. Norguet E, Dahan L, Gaudart J, Gasmi M, Ouafik L, Seitz JF. Cetuximab after bevacizumab in metastatic colorectal cancer: is it the best sequence? Dig Liver Dis Nov;43(11): (2011) 6. Twelves C, Scheithauer W, McKendrick J, Seitz JF, Van Hazel G, Wong A, Díaz-Rubio E, Gilberg F, Cassidy J. Capecitabine versus 5-fluorouracil/folinic acid as adjuvant therapy for stage III colon cancer: final results from the X-ACT trial with analysis by age and preliminary evidence of a pharmacodynamic marker of efficacy. Ann Oncol Sep 6. - (2011) 7. Ducreux M, Malka D, Mendiboure J, Etienne PL, Texereau P, Auby D, Rougier P, Gasmi M, Castaing M, Abbas M, Michel P, Gargot D, Azzedine A, Lombard-Bohas C, Geoffroy P, Denis B, Pignon JP, Bedenne L, Bouché O; Fédération Francophone de Cancérologie Digestive. Sequential versus combination chemotherapy for the treatment of advanced colorectal cancer (FFCD ): an open-label, randomised, phase 3 trial. Lancet Oncol Oct;12(11): (2011) 8. Minaya P, Baumstarck K, Berbis J, Goncalves A, Barlesi F, Michel G, Salas S, Chinot O, Grob JJ, Seitz JF, Bladou F, Clement A, Mancini J, Simeoni MC, Auquier P. The CareGiver Oncology Quality of Life questionnaire (CarGOQoL): Development and validation of an instrument to measure the quality of life of the caregivers of patients with cancer. Eur J Cancer Oct (2011) 9. Combes S., Barbier P., Douillard S., McLeer-Florin A., Rey V., Pierson JT., Fedorov A., Finet JP., Boutonnat J., Peyrot V. Synthesis and Biological Evaluation of 4-arylcoumarin Analogues of Combretastatin. J Med Chem, 2011, 12;54(9): (2011) 10. Tsvetkov P, Kulikova AA, Devred F, Zerni E, Lafitte D, Makarov AA Thermodynamics of calmodulin and tubulin binding to the vinca-alkaloid vinorelbine. Molecular Biology, 2011, 45(4): (2011) 11. Dahan L, Norguet E, Etienne-Grimaldi MC, Formento JL, Gasmi M, Nanni I, Gaudart J, Garcia S, Ouafik L, Seitz JF, Milano G. Pharmacogenetic profiling and cetuximab outcome in patients with advanced colorectal cancer. BMC Cancer Nov 25;11:496 - (2011) 12. Leloup L, Wells A. Calpains as potential anti-cancer targets. Expert Opin Ther Targets Mar;15(3): (2011) 13. Defilles C, Montero MP, Lissitzky JC, Rome S, Siret C, Luis J, André F, Rigot V. alphav integrin processing interferes with the cross-talk between alphavbeta5/beta6 and alpha2beta1 integrins. Biol Cell Nov;103(11): (2011) 14. Alhanout, K., Malesinski S., Vidal N., Peyrot V., Rolain JM., Brunel JM. New Insights on the Antibacterial Mechanism of Action of Squalamine. J. Antimicrob. Chemother., 2010, 65(8): (2010) 15. Rosmorduc O, Chevreau C, Dielenseger P, Ederhy S, Goldwasser F, Grange JD, Mortier L, Neidhardt-Berard ME, Robert C, Scotte F, Seitz JF. Guidelines for treatment of hepatocellular or renal carcinoma with sorafenib. Gastroenterol Clin Biol. 2010; 34: (2010) 16. Calligaris D, Verdier-Pinard P, Devred F, Villard C, Braguer D, Lafitte D. Microtubule targeting agents: from biophysics to proteomics. Cell Mol Life Sci Apr;67(7): (2010) 17. Bazaa A, Pasquier E, Defilles C, Limam I, Kessentini-Zouari R, Kallech-Ziri O, El Battari A, Braguer D, El Ayeb M, Marrakchi N, Luis J. MVL-PLA2, a snake venom phospholipase A2, inhibits angiogenesis through an increase in microtubule dynamics and disorganization of focal adhesions. PLoS One. 2010; 5: e (2010) 18. Kessentini-Zouari R, Jebali J, Taboubi S, Srairi-Abid N, Morjen M, Kallech-Ziri O, Bezzine S, Marvaldi J, El Ayeb M, Marrakchi N, Luis J. CC-PLA2-1 and CC-PLA2-2, two Cerastes cerastes venom-derived phospholipases A2, inhibit angiogenesis both in vitro and in vivo. Lab Invest. 2010; 90: (2010) 19. Mitry E, Hammel P, Deplanque G, Mornex F, Levy P, Seitz JF, Moussy A, Kinet JP, Hermine O, Rougier P, Raymond E. Safety and activity of masitinib in combination with gemcitabine in patients with advanced pancreatic cancer. Cancer Chemoth Pharm Jul;66(2): (2010) 20. Ciccolini J, Dahan L, Andre N, Evrard A, Duluc M, Blesius A, Yang C, Giacometti S, Brunet C, Raynal C, Ortiz A, Frances N, Iliadis A, Duffaud F, Seitz JF, Mercier C. Cytidine deaminase residual activity in serum is a predictive marker of early severe toxicities in adults after gemcitabine-based chemotherapies. J Clin Oncol. 2010; 28: (2010) 21. Limam I, Bazaa A, Srairi-Abid N, Taboubi S, Jebali J, Zouari-Kessentini R, Kallech-Ziri O, Mejdoub H, Hammami A, El Ayeb M, Luis J, Marrakchi N. Leberagin-C, A disintegrin-like/cysteine-rich protein from Macrovipera lebetina transmediterranea venom, inhibits alphavbeta3 integrin-mediated cell adhesion. Matrix Biol. 2010; 29: (2010) 22. Taboubi S, Garrouste F, Parat F, Pommier G, Faure E, Monferran S, Kovacic H, Lehmann M. Gqcoupled purinergic receptors inhibit insulin-like growth factor-i/phosphoinositide 3-kinase pathwaydependent keratinocyte migration. Mol Biol Cell. 2010; 21: (2010) 9/23

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19 3. Urien S, Firtion G, Anderson ST, Hirt D, Solas C, Peytavin G, Faye A, Thuret I, Leprevost M, Giraud C, Lyall H, Khoo S, Blanche S, Tréluyer JM. Lopinavir/ritonavir population pharmacokinetics in neonates and infants. Br J Clin Pharmacol Jun;71(6): Gerolami R, Barentain P, RaissouniF, Motte A, Solas C, Colson P. Treatment of severe acute hepatitis E by ribavirin. J Clin Virol Sep;52(1):60-2. Epub 2011 Jul Muret P, Piedoux S, Solas C, Quaranta S. [Evidence-based Therapeutic Drug Monitoring for Nevirapine]. Therapie May-Jun;66(3): Epub 2011 Aug 9. French. 6. Solas C, Gagnieu MC. [Evidence-based Therapeutic Drug Monitoring for Efavirenz]. Therapie May-Jun;66(3): Epub 2011 Aug 9. French. 7. Muret P, Solas C. [Evidence-based Therapeutic Drug Monitoring for Saquinavir]. Therapie May-Jun;66(3): Epub 2011 Aug 9. French. 8. Solas C, Muret P. [Evidence-based Therapeutic Drug Monitoring of Atazanavir]. Therapie May-Jun;66(3): Epub 2011 Aug 9. French. 9. Solas C, Pare M, Quaranta S, Stanke-Labesque F. [Evidence-based Therapeutic Drug Monitoring for Ribavirine]. Therapie May-Jun;66(3): Epub 2011 Aug 9. French. 10. Cordier PY, Nau A, Ciccolini J, Oliver M, Mercier C, Lacarelle B, Peytel E. 5-FU-induced neurotoxicity in cancer patients with profound DPD deficiency syndrome: a report of two cases. Cancer Chemother Pharmacol Sep;68(3): Roch A, Woloch C, Blayac D, Solas C, Quaranta S, Mardelle V, Castagnier M, Papazian L, Sampol- Manos E. Effect of fluid loading during hypovolaemic shock on caspofungin pharmacokinetic parameters in pig. Crit Care. 2011;15(5):R219. Epub 2011 Sep Launay O, Tod M, Tschöpe I, Si-Mohamed A, Bélarbi L, Charpentier C, Goujard C, Taburet AM, Lortholary O, Leroy V, Bélec L; ANRS EP24 GYNODYN Study Group. Residual HIV-1 RNA and HIV-1 DNA production in the genital tract reservoir of women treated with HAART: the prospective ANRS EP24 GYNODYN study. Antivir Ther. 2011;16(6): D. Barbolosi, F. Verga, B. You, A. Benabdallah and F. Hubert, et al. Modélisation du risque d évolution métastatique chez les patients supposés avoir une maladie localisée. Oncologie 2011, 13(8)8: Frances N, Claret L, Bruno R, Iliadis A. Tumor growth modeling from clinical trials reveals synergistic anticancer effect of the capecitabine and docetaxel combination in metastatic breast cancer. Cancer Chemother Pharmacol Apr [EPub ahead of print] 15. Chefrour M, Milano G, Formento P, Giacometti S, Denden A, Renée N, Iliadis A, Fischel JL, Ciccolini J. Positive interaction between lapatinib and capecitabine in human breast cancer models: study of molecular determinants. Fundam Clin Pharmacol Aug;26(4): doi: /j x. Epub 2011 May Guilhaumou R, Solas C, Bourgarel-Rey V, Quaranta S, Rome A, Simon N, Lacarelle B, André N. Impact of plasma and intracellular exposure and CYP3A4, CYP3A5, and ABCB1 genetic polymorphisms on vincristine-induced neurotoxicity. Cancer Chemother Pharmacol Dec;68(6): Epub 2011 Oct L. Dahan, J. Ciccolini, A.Evrard, L. Mbatchi, J. Tibbits, P. Ries, E. Norguet, C. Mercier, A. Iliadis L. Ouafik, B. Lacarelle, J.F. Seitz. Sudden toxic-death in a patient upon xeliri (capecitabine + irinotecan) plus bevacizumab intake: pharmacogenetic implications. J Clin Oncol. E41-4 Epub 2011 Dec Pasquier E, Ciccolini J, Carre M, Giacometti S, Fanciullino R, Pouchy C, Montero MP, Serdjebi C, Kavallaris M, André N. Propranolol potentiates the anti-angiogenic effects and anti-tumor efficacy of chemotherapy agents: implication in breast cancer treatment. Oncotarget Oct;2(10): Marouani H, Zografidis A, Iliadis A. Kinetic nomograms assist individualization of drug regimens. Clin Pharmacokinet Dec 1;50(12): Barbolosi, D, Verga, F, You, B, Benabdallah, A, Hubert, F Mercier, C, Ciccolini, J, Faivre, C. Model-based assessment of the risk of metastatic spreading in patients with localized cancer. Oncologie (8): Ciccolini J, Fina F, Ouafik LH, Lacarelle B. Pharmacogenetics and pharmacogenomics of colorectal cancer : moving towards personalized medicine. In: Colorectal Cancer: From Prevention to Patient Care Book 2, InTech 2011 ISBN: Ciccolini J, Evrard A, Lacarelle B. A CDD polymorphism as predictor of capecitabine-induced handfoot syndrome--letter. Clin Cancer Res Jan 1;18(1):317. No abstract available. 23. Dahan L, Ciccolini J, Evrard A, Mbatchi L, Tibbitts J, Ries P, Norguet E, Mercier C, Iliadis A, Ouafik L, Lacarelle B, Seitz JF. Sudden death related to toxicity in a patient on capecitabine and irinotecan plus bevacizumab intake: pharmacogenetic implications. J Clin Oncol Feb 1;30(4):e41-4. Epub 2011 Dec 19. No abstract available. 24. Ciccolini J, Mercier C, Dahan L, André N. Integrating pharmacogenetics into gemcitabine dosing-- time for a change? Nat Rev Clin Oncol Feb 8;8(7): Ciccolini J, Dahan L, André N, Evrard A, Duluc M, Blesius A, Yang C, Giacometti S, Brunet C, Raynal C, Ortiz A, Frances N, Iliadis A, Duffaud F, Seitz JF, Mercier C. Cytidine deaminase residual activity 19/23

20 in serum is a predictive marker of early severe toxicities in adults after gemcitabine-based chemotherapies.j Clin Oncol Jan 1;28(1): Le Guellec C, Bentué-Ferrer D; groupe STP de la SFPT. Therapeutic drug monitoring. Therapie Jan-Feb;65(1):13-5. French. No abstract available. PMID: [PubMed - indexed for MEDLINE] 27. Raynal C, Ciccolini J, Mercier C, Boyer JC, Polge A, Lallemant B, Mouzat K, Lumbroso S, Brouillet JP, Evrard A. High-resolution melting analysis of sequence variations in the cytidine deaminase gene (CDA) in patients with cancer treated with gemcitabine. Ther Drug Monit Feb;32(1): Yang CG, Ciccolini J, Blesius A, Dahan L, Bagarry-Liegey D, Brunet C, Varoquaux A, Frances N, Marouani H, Giovanni A, Ferri-Dessens RM, Chefrour M, Favre R, Duffaud F, Seitz JF, Zanaret M, Lacarelle B, Mercier C. DPD-based adaptive dosing of 5-FU in patients with head and neck cancer: impact on treatment efficacy and toxicity. Cancer Chemother Pharmacol Jan;67(1): Epub 2010 Mar Moreau E, André N, Coze C, Padovani L, Mercier C, Ciccolini J. Can CDA deficiency explain tumour lysis syndrome in a child with neuroblastoma receiving gemcitabine? Pediatr Blood Cancer May;54(5): No abstract available. 30. Chefrour M, Fischel JL, Formento P, Giacometti S, Ferri-Dessens RM, Marouani H, Francoual M, Renée N, Mercier C, Milano G, Ciccolini J. Erlotinib in combination with capecitabine (5'dFUR) in resistant pancreatic cancer cell lines. J Chemother Apr;22(2): Mercier C, Dahan L, Ouafik L, André N, Ciccolini J. Letter to the editor: pharmacokinetics of gemcitabine in non-small-cell lung cancer patients: impact of the 79A>C cytidine deaminase polymorphism. Eur J Clin Pharmacol Sep;66(9): Epub 2010 Jun 19. No abstract available. 32. Ciccolini J, Gross E, Dahan L, Lacarelle B, Mercier C. Routine dihydropyrimidine dehydrogenase testing for anticipating 5-fluorouracil-related severe toxicities: hype or hope? Clin Colorectal Cancer Oct;9(4): Ciccolini J. Le panitumumab en oncologie digestive : quel rationnel pharmacologique et pharmacocinétique? Oncologie 2010 Volume 12, Number 9, Ciccolini J, Dahan L, André N, Evrard A, Ouafik LH, Duffaud F, Seitz JF, Mercier C. Reply to Giovanetti et al. : Impact of Cytidine Deaminase Polymorphisms on Toxicity After Gemcitabine: The Question Is Still Ongoing. J Clin Oncol. May 10, 2010:e221-e222; published online on March 29, 2010; 35. Guilhaumou R,Simon N, Quaranta S, Verschuur A, Lacarelle B, Andre N, Solas C. Population pharmacokinetics and pharmacogenetics of vincristine in paediatric patients treated for solid tumour diseases. Cancer Chemother Pharmacol Dec 14. [Epub ahead of print] 36. Ciccolini, J. Panitumumab (Vectibix (R)) in digestive oncology: pharmacological and pharmacokinetic rationale Oncologie (9): Guilhaumou R, Lacarelle B, Sampol-Manos E. A rapid, simple and sensitive liquid chromatographytandem mass spectrometry method for routine clinical monitoring of tacrolimus with the Waters Masstrak immunosuppressant kit. Methods Find Exp Clin Pharmacol Dec;32(10): /23