Stabilis Noms commerciaux Cordilox Isoptin Grande Bretagne Autriche, Grande Bretagne, Italie, Pays bas France Espagne Grande Bretagne Danemark Finlande Isoptine Manidon Securon Veraloc Verpamil Stabilité des solutions Stabilité en mélange Dobutamine hydrochloride : 0,25 mg/ml 22 C-23 C Milrinone lactate : 0,35 mg/ml 4 191 1,25 mg/ml 22 C-23 C Milrinone lactate : 0,1 mg/ml 4 191 0,1 & 0,4 mg/ml 24 C Theophylline : 0,4 & 4 mg/ml 24 32 Dobutamine hydrochloride : 0,25 mg/ml 1 mg/ml Facteur influençant la stabilité 1100 PH > 1098 1099 www.stabilis.org - 31/12/201 12:14 - Page 1
Incompatibilités : 0,1 & 0,4 mg/ml Aminophylline : 1 mg/ml 364 1100 : 2.5 mg/ml Aminophylline : 25 mg/ml : 80 mg/ml Amphotericin B : 0.1 mg/ml : 2,5 mg/ml Amphotericin B cholesteryl sulfate complex : 0,83 mg/ml : 2.5 mg/ml Ampicillin sodium : 40 mg/ml : 80 mg/ml Co-trimoxazole : 80 mg/ml Dobutamine hydrochloride : 0.5 mg/ml : 0.5 mg/ml Furosemide : 1 mg/ml : 80 mg/ml Hydralazine hydrochloride : 0.04 mg/ml : 2.5 mg/ml Lansoprazole : 0.55 mg/ml Nafcillin sodium Nafcillin sodium : 2.5 mg/ml Nafcillin sodium : 40 mg/ml : 2.5 mg/ml Oxacillin sodium : 40 mg/ml Pantoprazole sodium : 2.5 mg/ml Propofol Sodium bicarbonate 06 921 31 1232 1625 1351 1099 31 31 2090 6 1100 Voie d administration www.stabilis.org - 31/12/201 12:14 - Page 2
Type 191 Revue Source Riley CM. Stability of milrinone and digoxin, furosemide, procainamide hydrochloride, propranolol hydrochloride, quinidine gluconate, or verapamil hydrochloride in 5% dextrose injection. 364 Revue 31 Revue 32 Revue 6 Revue Am J Hosp Pharm 1988 ; 45: 209-2091. Johnson CE, Lloyd CW, Mesaros JL, Rubley GJ. Compatibility of aminophylline and verapamil in intravenous admixtures. Am J Hosp Pharm 1989 ; 46: 9-100. Thompson DF, Stiles ML, Allen LV, Tu YH. Compatibility of verapamil hydrochloride with penicillin admixtures during simulated Y-site injection. Am J Hosp Pharm 1988 ; 45: 142-145. Johnson CE, Lloyd CW, Aviles AI, Rybarz KL. Compatibility of premixed theophylline and verapamil intravenous admixtures. Am J Hosp Pharm 1988 ; 45: 9-612. Michaels MR, Stauffer GL, Haas DP. Propofol compatibility with other intravenous drug products - Two new methods of evaluating IV emulsion compatibility. 06 Revue 921 Revue Ann Pharmacotherapy 1996 ; 30: 228-232. Cutie MR. Compatibility of verapamil hydrochloride with other additives. Am J Hosp Pharm 1981 ; 38: 231. Trissel LA, Gilbert DL, Martinez JF. Incompatibility and compatibility of amphotericin B cholesteryl sulfate complex with selected other drugs during simulated Y-site administration. Revue Hosp Pharm 1998 ; 33: 284-292. Das Gupta V, Stewart KR. Stability of dobutamine hydrochloride and verapamil hydrochloride in 0.9% sodium chloride and 5 % dextrose injections. Revue 1098 Revue 1099 Revue 1100 Revue 1232 Revue 1351 Revue Am J Hosp Pharm 1984 ; 41: 686-689. Cutie MR. Compatibility of verapamil hydrochloride injection with commonly used additives. Am J Hosp Pharm 1983 ; 40: 1205-120. Cutie MR. Verapamil precipitation. Ann Intern Med 1983 ; 98: 62. Tucker R, Gentile JF. Precipitation of verapamil in an intravenous line. Ann Intern Med 1984 ; 101: 880. Bar-Or D, Kulig K, Marx JA, Rosen P. Precipitation of verapamil. Ann Intern Med 1982 ; 9: 619. Beatson C, Taylor A. A physical compatibility study of furosemide & flucloxacillin injections. Br J Pharm Pract 198 ; 9: 223-226, 236. Tucker R, Gentle JF. Precipitation of verapamil with nafcillin. Am J Hosp Pharm 1984 ; 41: 2588. www.stabilis.org - 31/12/201 12:14 - Page 3
1625 Revue 2090 Revue Trissel LA, Saenz C, Williams YW, Ingram D. Incompatibilities of lansoprazole injection with other drugs during simulated Y-site coadministration. Int J Pharm Compound 2001 ; 5: 314-321. Pere H, Chasse V, Forest JM, Hildgen P. Compatibility of injectable pantoprazole in Y-site administration. Pharmactuel 2004 ; 3: 193-196. www.stabilis.org - 31/12/201 12:14 - Page 4
Stabilis Stabilité des préparations 2500 mg Verapamil Hydrochloride SyrSpend SF >>50ml 2-8 C 3209 3209 ml 00 mg =? (Schein Pharmaceutical) OraPlus / OraSweet (1:1) >> 1202 120 ml 00 mg =? (Schein Pharmaceutical) OraPlus / OraSweet SF (1:1) >> 2 00 mg =? (Schein Pharmaceutical) Sirop cerise / sirop simple (1:4) >> 120 2ml ml 00 mg =? (Schein Pharmaceutical) OraPlus / OraSweet (1:1) >> 120 120 ml 00 mg =? (Schein Pharmaceutical) OraPlus / OraSweet SF (1:1) >> 00 mg =? (Schein Pharmaceutical) Sirop cerise / sirop simple (1:4) >> 120 ml 50 ml 2500 mg Verapamil Hydrochloride OraPlus / OraSweet SF (1:1) >> 2-8 C Type Revue Source Allen LV, Jr, Erickson MA, Stability of labetalol hydrochloride, metoprolol tartrate, verapamil hydrochloride, and spironolactone with hydrochlorothiazide in extemporaneously compounded oral liquids 3209 Revue Am J Health-Syst Pharm 1996 ; 53: 2304-2309. Voudrie Mark A, Alexander Bridget, Allen D Brett. Stability of Verapamil Hydrochloride in SyrSpend SF Compared to Sorbitol Containing Syrup and Suspending Vehicles. Int J Pharm Compound 2011 ; 15, 3: 255-258. www.stabilis.org - 31/12/201 12:14 - Page 5
Dictionnaire Antiarythmique Injectable Noms commerciaux Stabilité des solutions Contenant Molécule Concentration Température Conservation Heure Biosimilaire Données conflictuelles Verre NaCl 0,9% ou glucose 5% A l abri de la lumière Jour Polyvinyl chlorure Stabilité en mélange Solvant Molécule Glucose 5% Lumière Heure Facteur influençant la stabilité NaHCO3 Provoque Dégradation Précipitation Incompatibilités Chlorure de sodium 0,9% Chlorure de sodium 0,45% Voie d administration Intraveineuse Perfusion intraveineuse Vasodilatateur Solution buvable Stabilité des préparations Origine Excipient Flacon plastique Poudre Non précisée Comprimés Dictionnaire www.stabilis.org - 31/12/201 12:14 - Page 6