M2 Recherche : Sciences du médicament Skin Delivery Responsable : Professeur Françoise FALSON Tel : 04.78.77.71.11 / Fax : 04.78.77.72.47 falson@univ-lyon1.fr PRESENTATION ET PROGRAMME 2011-2012 Présentation des UE UE1 Propriété intellectuelle des médicaments, Documentation scientifique UE2 Mathématiques et Statistiques UE11 Absorption cutanée et formulation UE16 Physiologie et biodisponibilités cutanées UE17 Formulation pratique et tests d activité UE Initiation à la recherche UE Stage 3 ECTS 3 ECTS 30 ECTS Planning UE1 Semaine 42 et 11/10/2011 UE2 Semaines 44, 45 et 46 UE11 Semaine 40 UE16 Semaine 41 UE17 Semaine 43 UE Initiation à la recherche Semaine 47 UE Stage Semaines 01 à 26 Examens Semaine 50
UEs 11 et 16 EMPLOI DU TEMPS European Lifelong Learning Program/Erasmus Intensive Program Advanced Delivery Strategies for Pharmaceutics and Cosmetics Lyon 3 rd - 14 th October 2011 From the 3 rd to the 7 th, the conferences will take place at: ISPB Faculty of Pharmacy - Salle du Conseil Level 1, Stair A 3 rd - 4 th October Session I: Skin delivery Monday, October 3 rd, 2011 9 10 am Welcome and Presentation 10 11 am Marek Haftek University of Lyon Normal and pathological functions of the skin barrier 11 12 Fabrice Pirot University of Lyon Transcutaneous gas exchanges 2 3 pm Anne Sirvent Laboratoire Dermscan Safety and efficacy evaluation of products in vivo in man 3 4 pm Fabrice Pirot University of Lyon Current and new strategies for antimicrobial skin delivery Tuesday, October 4 th, 2011 10 11 am Estelle Tessonneaud and Nathalie Seyler Episkin Reconstructed skin evaluation research tools 11 12 Valérie Bertholle University of Lyon Skin cancers 2 3 pm Yogeshvar Kalia University of Geneva Iontophoresis: Delivering charged molecules across biological membranes; Part 1 Principles, transport mechanisms and effect on skin 3 4 pm Yogeshvar Kalia University of Geneva Iontophoresis: Delivering charged molecules across biological membranes; Part 2 Clinical applications - Case studies for local and systemic delivery and therapeutic monitoring 4 5 pm Steffi Hansen University of Saärbrucken In vitro studies, Methodology for skin absorption 5 th - 6 th October Session II: Drug development, Formulation Wednesday, October 5 th, 2010 9 10 am Laurène Roussel University of Lyon Surfactants as skin penetration modulators 10 11 am Mirjana Gasperlin University of Ljubljana - Microemulsions 11 12 Marie-Geneviève Dijoux University of Lyon New drugs from plants 2 3 pm Laëtitia Cattuzzato Seppic - 3 5 pm Helena Marques University of Lisboa Cyclodextrins in drug development and formulation Thursday, October 6 th, 2010 9 10 am 10 11 am Daniel Kurbiel Polaar - The development process of a polar concept cosmetic range 11 12 Frédéric Thareau Polaris Technical approach for high potency healthcare and skincare ingredients 2 3 pm Nicolas Atrux-Tallau Capsum - Nanoemulsions 3 4 pm Françoise Falson University of Lyon Skin absorption modulation 4 5 pm Jean-François Nicolas University of Lyon Skin immune system
7 th October Session III: Pulmonary delivery Friday, October 7 th, 2010 9 10.30 am Carsten Ehrhardt Trinity college, Dublin - Anatomy and physiology of the respiratory tract 10.30 12 Fabio Sonvico University of Parma Drug delivery to the lung 2 3.30 pm Carsten Ehrhardt Trinity college, Dublin - In vitro models of respiratory drug delivery 3.30 5 pm Fabio Sonvico University of Parma Nanoparticles as pulmonary drug delivery systems From the 10 th to the 14 th, the laboratory sessions will take place in different locations, please refer to the laboratory session document. 10 th - 14 th October Laboratory Sessions Monday, October 10 th, 2011 8 11 Chlorhexidine gel, formulation and microbiology (part 1) 11 12 Jean Freney University of Lyon Skin microflora 2 5 pm Transdemal delivery system, formulation (part 1) Wednesday, October 12 th, 2010 9 10 am Chlorhexidine gel, microbiology (part 2) 10 12 Confocal microscopy (part 1) Yves Tourneur 2 4 pm Confocal microscopy (part 2) 4 6 pm Audrey Guéniche - L Oréal - Thursday, October 13 th, 2010 9 12 Anne-Cécile Dontot Seppic - 2 6 pm Stéphane Lebras - Thermo Electron - Friday, October 14 th, 2010 9 12 Transdermal delivery system (part 2) 2 6 pm Transdermal delivery system (part 3)
UE 1 Conférence inaugurale: Marc LE BORGNE 18 octobre 2011, 10h-12h Salle du Conseil Conférences INPI: Céline MATHEVET 18 octobre 2011, 14h-16h Salle du Conseil Ines TRIPOZ 19 octobre 2011, 10h-12h Salle du Conseil Carole BREMEERSCH 20 octobre 2011, 10h-12h Salle du Conseil Guillaume BRUNEL 21 octobre 2011, 10h-12h Salle des thèses 1 Travaux dirigés : - Séance 1 : méthodes de base et applications et Séance 2 : bases de données de référence Pascal BADOR 11 octobre 2011 Salle informatique - Séance 3 : accès aux brevets Laurent ETTOUATI 21 octobre 2011, 14-16h Salle informatique - Séance 4 : logiciels scientifiques Laurent ETTOUATI 20 octobre 2011, 14h-16h Salle informatique - Séance 5 : rédaction scientifique et démarrage du TPE Pascal BADOR date à définir Salle informatique UE 17 From the 24 th to the 28 th, the laboratory sessions will take place at: Salle de TP du Laboratoire de Pharmacie Galénique Level 2, Stair C Monday, October 24 th, 2011 9.30 12 Lectures: Emulsions and Gels Introduction to Rheology 2 6 pm Formulation of ternary diagram (oil, water, surfactant) Tuesday, October 25 th, 2011 9 12 Difference of UV transmittance through stratum corneum in different ethnic skins 2 6 pm Skin hydration: Comparison between Emulsion and Microemulsion Wednesday, October 26 th, 2010 9 am 6 pm Formulation and characterization of tanning effect of Dihydroxyacetone loaded liposomes (proliposomes) and Ethosomes Thursday, October 27 th, 2010 9 am 6 pm Formulation and rheological characterization of a topical preparation containing cafeine Friday, October 28 th, 2010 9 am 6 pm Formulation and characterization of sun products
UE 2 Monday, October 31st, 2011 10-12 MA Dronne Lecture and exercises: Mathematical functions and differential equations Wednesday, November 2nd, 2011 2-4pm MA Dronne Lecture and exercices: Population pharmacokinetics and Pharmacodynamics Thursday, November 3rd, 2011 Lecture and exercises: Experimental design, descriptive statistics Friday, November 4th, 2011 Lecture and exercises: the variances Parametric hypothesis tests for the means, the proportions and Monday, November 7th, 2011 Lecture and exercises: Analysis of variance (ANOVA) Wednesday, November 9th, 2011 2-4 pm MA Dronne Lecture and exercises: Nonparametric hypothesis tests Tuesday, November 15th, 2011 8-10am MP Gustin Lecture and exercices: Linear regression, correlation, calibration curves 2-4 pm MP Gustin Lecture: Initiation to statistical multivariate analysis, application to release kinetics Wednesday, November 16th, 2011 2-5 pm MP Gustin Salles informatique 3 and 4 Practice: Linear regression, correlation, calibration method Friday, November 18th, 2011 2-5 pm MP Gustin Salles informatique 3 and 4 Statistical practice in pharmaceutics (recap) (MP Gustin) UE Initiation à la recherche 21, 23, 24 et 25 Novembre 2011