Professor, Director of Research, Head of Laboratory Physiology- Pharmacology-Environmental Health

Transcription

1 CURRICULUM VITAE Name : Surname: Position: Date of birth : Marital status : Address : (Mme) Lyoussi Badiaâ Professor, Director of Research, Head of Laboratory Physiology- Pharmacology-Environmental Health November 24 th 1958, Sefrou, Morocco. Married, five children. Department of Biology, Experimental and clinical pharmacology group. Laboratory of Physioloy pharmacology-environmemtal health, UFR : Physiology-Pharmacology,University of Fez, POBox 1796 Fez Atlas, Fez, Morocco Tel : W: D: : mobile : Fax : E. Mail : lyoussi@rocketmail.com or lyoussi@menara.ma lyoussi@gmail.com UNIVERSITY FORMATION Years University / Institution 1981 Licence in Biology - Geology University Mohamed V, Fac Sci. Rabat Morocco 1982 DEA in Endocrinology and U.S.T.L, Montpellier, France Development (AB) 1984 Doctorat in Neuroendocrinologie (TB) U.S.T.L. Montpellier, France ( Prof J.D. BAYLE) 1992 Doctorat ( Scientific grade) Catholic University of louvain very high distinction Belgium Pr Crabbé. J

2 ACADEMIC APPOINTMENTS * EDUCATION : Professor Assistant l'ecole Normale Supérieure of Fès : Professor assistant, Faculty of Sciences Dhar-Mahraz : Stage of 3 years in Brussels, Belgium, obtention of Second Doctorat : Professor of Physiology-Pharmacology, Faculty of Sciences Dhar-Mahraz, Responsable of courses of Endocrinology, Renal Physiology, Neurophysiology and cellular physiology and practical Workshops. Participation in courses of DEA BIOLOGY AND HEALTH in Marrakech, Responsable of high level courses «: MOLECULAR AND CELLULAR ENDOCRINOLOGY» * RESEARCH EXPERIENCE Head of Unity of Formation and Research in Physiology-Pharmacology Doctorale Formation entitled : Medicinal plants with therapeutic effects : Physiological and toxico-pharmacological studies DESA Formation ( Master) entitled : Molecular and cellular physiopathology Supervision of superior studies and PhD. Students at the Faculty of Science, Faculty of Medicine, Nurses in Public Hospitals, Doctors, Ingeniors and Arabic researchers ( Yemen, Jordan, Mauritany, Algeria, Comores, etc. - Master projects : 13 - PhD : 40 Supervise staff working in the Laboratory Physiology-Pharmacology & Environmental Health in the areas of: (i). Research and development, (ii).medicinal plants research, quality control (iii). Biomarkers of pollution and health impact. (iv). Organize training programs, symposium and international conferences International link: Maintaining good contacts or working closely with scientific group leaders in the European and American Universities, organizations, institutions and herbaceutical and pharmaceutical industries related to projects and programs in research and scientific knowledge in Advance Pharmacology, Alternative Medicine and Pharmaceutical Molecular pathologies ( Diabete, obesity, hypertension, resistance to antibiotic ). 2

3 Scientific Presentation: Presenting scientific papers in the national and international conferences and meetings related to the advance/complementary medicine and medicinal plants technologies in cardiovascular, metabolic pathologies, and the new biopharmaceuticals molecules, environmental health and impacts of polluants Research topics : Screening and collection of data concerning regional and national valorisation of medicinal plants and their use by population and establishing a formal application by contacting traditional herborists Heavy metals, environment and health Hormonal and metabolic control of kidney function: Effects of depurative medicinal plants Physiopathology of diabete : Implications of medicinal plants Intoxication by heavy metals : Models of renal failure Acute and chronic toxicity of extracts of Moroccan medicinal plants Genetic models of hypertension : Therapeutic effects of medicinal plants Genetic models of obesity : Effects of natural remedies Biological and genetic abnormalities of diabete, obesity, hypertension in susceptible population Impact of heavy metals and environmental polluants on biomarkers of kidney in children, teenagers, women SCIENTIFIC PUBLICATIONS 1. Lyoussi, B., Beaujean, V. & Crabbé, J. (1989). Influence of aldosterone on conductive chloride movement across amphibian skin. Arch. Int. Physiol. Biochim 98 : P67- P68 2. Lyoussi, B., Granitzer, M., Nagel, W. & Crabbé, J. (1991). Effect of dexamethasone on regulation of Na transport in cultured renal distal cells. Arch. Int. Physiol. Biochim 99 (2) P18 3. Granitzer, M., Lyoussi, B., Nagel, W. & Crabbé, J. (1991). Effect of dexamethasone on membrane properties in cultured renal distal cells (A6). Cell Physiol. Biochem, I : Granitzer, M., Lyoussi, B., Nagel, W. & Crabbé, J. (1991). Effect of oxytocin on elctrophysiology of cultured renal distal epithelia. Arch. Int. Physiol. Biochim 99 (2) : P31 5. Granitzer, M., Lyoussi, B., Nagel, W. & Crabbé, J. (1991). Apical Na + entry in cultured renal distal epithelia (A6). International Symposium on aldosterone, 1991, France. Aldosterone Fundamental aspects Ed by J.P Bonvalet, N, Farman, M Lombès, ME Rafestin-Oblin. Vol 215 p Granitzer, M., Lyoussi, B., Nagel, W. & Crabbé, J. (1991). Effect of dexamethasone on membrane conductance and ( Na + + K + ) / ATPase activity in cultured A6 cells. 70; Tagung der Deutschen Physiologischen Gesellschaft, Sawt 1991 in Freiburg, Germany, Pflügers Archiv 419 ( Suppl N 1) : R97 ( 118) 7. Lyoussi, B. & Crabbé, J. (1991). Modulation of ( Na + + K + ) / ATPase by apical Na + entry in culturd renal distal epithelial cells. Pflügers Arch 419 : R8 8. Lyoussi, B. & Crabbé, J. (1991). Stimulation du transport de Na + par la dexaméthasone dans une lignée épithéliale rénale en culture. Arch. Int. Physiol. Biochim 99 : A197 3

4 9. Lyoussi, B., Beaujean, V. & Crabbé, J. (1991). Corrélation entre l'entrée apicale du Na + et l'activité de la ( Na + + K + )-ATPase dans une lignée épithéliale rénale en culture (A6). Arch. Int. Physiol. Biochim 99: A Lyoussi, B. & Crabbé, J. (1992). Influence of osmolality on transepithelial Na + transport by A6 line ( A6) derived from the distal renal tubule of Xenopuis laevis. Arch. Physiol. Biochim, 100 (1) : P4 11. Lyoussi, B. & Crabbé, J. (1992). Relationship between Na + tranport rate and ( Na + + K + )-ATPase in A6 cells : Effect of low ambient K +. Arch. Int. Physiol. Biochim 100 (2) P Lyoussi, B. & Crabbé, J. (1992). Influence of apical Na + entry on ( Na + + K + ) -ATPase in amphibien distal nephron cells (A6). J. Physiol ( london) : 456: pp Lyoussi, B. & Crabbé, J. (1995). Effect of steroid hormones and peptides on the regulation of ( Na + + K + )- ATPase in tight epithelia. Pflügers Arch. Vol 430 N 4, R Lyoussi. B & J. Crabbé. (1996) Effects of corticosteroids on parameters related to Na + transport by amphibian renal distal cells (A6) in culture. J. Steroid. Biochem. & Mol. Biol. Vol 59, N 3/4 pp: Lyoussi. B. & J. Crabbé. (1996) Effects of dexamethasone on (Na + + K + )-ATPase and other parameters related to transepithelial Na + transport by amphibian renal distal cells (A6) in culture. J. Steroid. Biochem. & Mol. Biol. Volume 59, N 3 / 4 pp: B. Lyoussi, H. Rhiouani and A. Settaf. Diuretic effects of extracts of Herniaria glabra in rats. Autumn Meeting 16 November 1996, Gent, Belgium. Pflügers Arch. Eur. J. Physiol., 1997, 433: R5-R B. Lyoussi, H. Rhiouani, A. Settaf, Y. Cherrah and M. Hassar. Diuretic and antihypertensive effects of saponins from Herniaria glabra in spontaneous hypertensive rats (SHR). XIIIth International Congress of Pharmacology July 1998, Munchen, Germany. Archives of Pharmacology, supplement 1 to volume 358 Nº1, B. Lyoussi, Lotfi, A., D. Chabardès. PGE2 and carbachol induces an inhibition of camp in the glucagon sensitive cells of the rat OMCD. International Congress of Pharmacology, Munchen, Allemagne, juillet 1998, Arch of Pharmacology, supplement 1 V358(2), F. Lamchouri, A. Settaf, Y. Cherrah, M. Zemzami, B. Lyoussi, A. Zaid, N. Atif, M. Hassar ( 1999). Antitumor principles from Peganum harmala seeds. Therapie, H. Rhiouani, A. Settaf, B. Lyoussi, Y. Cherrah et M. Hassar. Action diurétique des saponines de Herniaria glabra chez le rat spontanément hypertendu. Espérance Médicale, 1999, 47: H. Rhiouani, A. Settaf, B. Lyoussi, Y. Cherrah et M. Hassar (1999). Effects of saponins from Herniaria glabra on blood pressure and renal function in spontaneously hypertensive rats. Therapie 54 (6) M. Haloui, J.Baptiste Michel, B. Lyoussi (2000). Experimental diuretic effects of Rosmarinus officinalis and Centaurium erythrea. J. Ethnopharmacology 71 (3) M. Haloui, J.F. Arnal, I. Pham, W. Gonzalez, B. Lyoussi, J.Baptiste Michel (2000). Functional Compartmentation of endocrine actions of cardiac natriuretic peptides. Ann Endocrinol ( Paris) 61(1) F. Lamchouri, A. Settaf, Y. Cherrah, M. Hassar, M. Zemzami, N. Atif, E.B. Nadori, A. Zaid, B. Lyoussi ( 2000). In vitro cell toxicity of Peganum harmala seedsalkaloids on cancerous cell-lines. Fitoterapia, 71 (1) H. Jouad, M. Eddouks, MA Lacaille-Dubois, B. Lyoussi (2000). Hypoglycaemic effect of the water extract of Spergularia purpurea in normal and streptozotocin induced-diabetic rats. Journal of Ethnopharmacology 71 ( 1-2)

5 26. Emery, E, Rhrich-Haddout, F, Kassar-Duchossoy, L, Lyoussi, B, Tadie, M, Horvat, C. (2000). Motoneurons of the adult marmoset can grow axons and reform motor endplates through a peripheral nerve bridge oining the locally injured cervical spinal cord to the denervated biceps brachii muscle. J. Neurosci. R 62 (6) H. Rhiouani, B. Lyoussi, A. Settaf, Y. Cherrah et M. Hassar ( 2001 ). Antihypertensive effect of Herniaria glabra saponins in the spontaneously hypertensive rat Ann Pharm Fr, 59(3), M. Benwahhoud, H. Jouad, M. Eddouks, B. Lyoussi.(2001) Hypoglycemic effect of Suaeda fruticosa in streptozotocin-induced diabetic rats.j. Ethnopharmacology, 76 (1) : H. Jouad, MA Lacaille-Dubois, B. Lyoussi, M. Eddouks ( 2001). Effects of the flavonoids extracted from spergularia purpurea Pers. on arterial blood pressure and renal function in normal and hypertensive rats. Journal of Ethnopharmacology 76 ( 2) S. El Bardai, B. Lyoussi, M. Wibo, N. Morel ( 2001 ) Pharmacological evidence of hypotensive effects of marrubium vulgare and foeniculum vulgare in spontaneously hypertensive rats. Clinical and experimental hypertension, vol 23 ( 4), Rhrich-Haddout. F, Kansar Duchossoy, L., Bauchet, L. D, Destombes, J., Thiesson, D., Butler-Browne, G, Lyoussi, B, Baillet-Derbin, C, Horvat, JC. ( 2001). Alpha motoneurons of the injured cervical spinal cord of the adult rat can reinnervate the biceps brachii muscle by regenerating axons through peripheral nerve bridges : combined ultrastructural and retrograde axonal tracing study. J. Neurosci. Res, 64 ( 5) : F. Lamchouri, A. Settaf, Y. Cherrah, M. El Hamidi, NS. Tligui, B. Lyoussi, M. Hassar. Experimental toxicity of Peganum harmala seeds, Ann Pharm Fr. 60 (2), 123-9, J. Hilali and B. Lyoussi ( 2002) Hypoglycaemic effect of the lyophilised aqueous extract of Ajuga iva in normal and streptozotocin diabetic rats. J. Ethnopharmacology, vol 80, B. Lyoussi, M.A. Ragala, A. Chraibi, S. Mantovani, H. De Togni ( 2002). Riduzione del sovrappeso attraverso l assunzione di aminoform 1000, associato ad un regime calorico controllato e attivita fisica, 1-16 Edition Akros, Italie 35. El-Bardai S, Wibo M, Hamaide MC, Lyoussi B, Quetin-Leclercq J, Morel N. Characterisation of marrubenol, a diterpene extracted from Marrubium vulgare, as an L-type calcium channel blocker. Br J Pharmacol Dec;140(7): Epub 2003 Nov El-Hilaly J, Hmammouchi M, Lyoussi B. Ethnobotanical studies and economic evaluation of medicinal plants in Taounate province (Northern Morocco). J Ethnopharmacol Jun;86(2-3): El Bardai S, Morel N, Wibo M, Fabre N, Llabres G, Lyoussi B, Quetin-Leclercq J. The vasorelaxant activity of marrubenol and marrubiin from Marrubium vulgare. Planta Med Jan;69(1): El Bardai S, Lyoussi B, Wibo M, Morel N. Comparative study of the antihypertensive activity of Marrubium vulgare and of the dihydropyridine calcium antagonist amlodipine in spontaneously hypertensive rat. Clin Exp Hypertens Aug;26(6): El-Hilaly J, Lyoussi B, Wibo M, Morel N. Vasorelaxant effect of the aqueous extract of Ajuga iva in rat aorta. J Ethnopharmacol Jul;93(1): El Bardai S, Hamaide MC, Lyoussi B, Quetin-Leclercq J, Morel N, Wibo M. Marrubenol interacts with the phenylalkylamine binding site of the L-type calcium channel. Eur J Pharmacol May 25;492(2-3):

6 41.El Hilaly J, Israili ZH, Lyoussi B. Acute and chronic toxicological studies of Ajuga iva in experimental animals. J Ethnopharmacol Mar;91(1): A.Touzani, M. candito, L. Chabraoui, A. Balafrej, B. Benhamou, B. Lyoussi, M. Lahrichi ( 2004). L homoicystéinémie et le phosphate de pyridoxal chez les enfants et les jeunes diabétiques de type 1, Revue Française des Laboratoires, 363, Lyoussi B, Ragala MA, Mguil M, Chraibi A, Israili ZH. Gender-specific leptinemia and its relationship with some components of the metabolic syndrome in Moroccans. Clin Exp Hypertens May;27(4): Haddad, P, Le and B. Lyoussi. Antidiabetic plants of North Africa and the Middle East. (2005) Book Volume Traditional Herbal Medicines for Modern Times - Antidiabetic Plants Chapter 12, pp Taylor &Francis 45. Lyoussi B, Ragala MA, Mguil M, Chraibi A, Israili ZH ( 2005) Gender-specific leptinemia and its relationship with some components of the metabolic syndrome in Moroccans. Clin Exp Hypertens. May;27(4): El-Hilaly J, Tahraoui A, Israili ZH, Lyoussi B ( 2006 ) Hypolipidemic effects of acute and sub-chronic administration of an aqueous extract of Ajuga iva L. whole plant in normal and diabetic rats. J Ethnopharmacol May 24;105(3): Tahraoui A, El-Hilaly J, Israili ZH, Lyoussi B ( 2006) Ethnopharmacological survey of plants used in the traditional treatment of hypertension and diabetes in southeastern Morocco (Errachidia province). J Ethnopharmacol Sep 23 9/ Zafar H. Israili, Lyoussi Badiâa; Velasco Manuel; 2006; 1(3): ; 1(3): 8-23 Metabolic syndrome : treatment of hypertensive patients with this syndrome Revista Latinoamericana de Hipertensión. Vol. 1 Nº 4, El-Hilaly J, Tahraoui A, Israili ZH, Lyoussi B. Acute hypoglycemic, hypocholesterolemic and hypotriglyceridemic effects of continuous intravenous infusion of a lyophilised aqueous extract of Ajuga iva L. Schreber whole plant in streptozotocin-induced diabetic rats. Pak J Pharm Sci Oct;20(4): Lahlou S, Tahraoui A, Israili Z, Lyoussi B ( 2007) Diuretic activity of the aqueous extracts of Carum carvi and Tanacetum vulgare in normal rats. J Ethnopharmacol. Ethnopharmacol Apr 4;110(3): Israili ZH, Lyoussi B, Hernández-Hernández R, Velasco M. Metabolic syndrome: treatment of hypertensive patients. Am J Ther Jul-Aug;14(4): Review. 51.El-Hilaly J, Tahraoui A, Israili ZH, Lyoussi B. Acute hypoglycemic, hypocholesterolemic and hypotriglyceridemic effects of continuous intravenous infusion of a lyophilised aqueous extract of Ajuga iva L. Schreber whole plant in streptozotocin-induced diabetic rats. Pak J Pharm Sci Oct;20(4): Lahlou S, Tahraoui A, Israili Z, Lyoussi B. 6

7 Diuretic activity of the aqueous extracts of Carum carvi and Tanacetum vulgare in normal rats. J Ethnopharmacol Apr 4;110(3): Epub 2006 Oct Tahraoui A, El-Hilaly J, Israili ZH, Lyoussi B. Ethnopharmacological survey of plants used in the traditional treatment of hypertension and diabetes in southeastern Morocco (Errachidia province). J Ethnopharmacol Mar 1;110(1): Epub 2006 Sep El AY, Berraho M, Benslimane A, Chrit M, El Hassani H, Lyoussi B, Nejjari C. Diabetes and erectile dysfunction in Morocco: epidemiological study among outpatients] East Mediterr Health J Sep-Oct;14(5): French. 55. El Achhab.Y, El Fakir S, Ouédraogo N, El Rhazi K, Berraho A, Lyoussi B, Nejjari C. Accidents d Exposition au Sang (AES) et dispositif de prise en charge: résultats d une enquête réalisée auprès des professionnels de santé Cahiers du Médecin (sous presse). 56. El Achhab Y, Meyre D, Bouatia-Naji N, Berraho M, Deweirder M, Vatin V, Delplanque J, Serhier Z, Lyoussi B, Nejjari C, Froguel P, Chikri M.(2008) Association of the ENPP1 K121Q polymorphism with type 2 diabetes and obesity in the Moroccan population. Diabetes Metab Nov Lahlou S, Tangi KC, Lyoussi B, Morel N ( 2008) Vascular effects of Tanacetum vulgare L. leaf extract: in vitro pharmacological study. J Ethnopharmacol Oct 30;120(1): M'guil M, Ragala MA, El Guessabi L, Fellat S, Chraibi A, Chebraoui L, Israili ZH, Lyoussi B (2008) Is Ramadan fasting safe in type 2 diabetic patients in view of the lack of significant effect of fasting on clinical and biochemical parameters, blood pressure, and glycemic control? Clin Exp Hypertens Jul;30(5): Rhiouani H, El-Hilaly J, Israili ZH, Lyoussi B. ( 2008) Acute and sub-chronic toxicity of an aqueous extract of the leaves of Herniaria glabra in rodents. J Ethnopharmacol Aug 13;118(3): Epub 2008 May Lahlou S, Israili ZH, Lyoussi B ( 2008) Acute and chronic toxicity of a lyophilised aqueous extract of Tanacetum vulgare leaves in rodents. J Ethnopharmacol May 8;117(2): El Achhab Y, Nejjari C, Chikri M, Lyoussi B. Disease-specific health-related quail ty of life instruments among adults diabetic: A systematic review. Diabetes Res Clin Pract May;80(2): Cherkaoui-Tangi K, Lachkar M, Wibo M, Morel N, Gilani AH, Lyoussi B. Pharmacological studies on hypotensive, diuretic and vasodilator activities of chrysin glucoside from Calycotome villosa in rats. Phytother Res Mar;22(3): Aissaoui A, El-Hilaly J, Israili ZH, Lyoussi B. Acute diuretic effect of continuous intravenous infusion of an aqueous extract of Coriandrum sativum L. in anesthetized rats. J Ethnopharmacol Jan 4;115(1): El AY, Berraho M, Benslimane A, Chrit M, El Hassani H, Lyoussi B, Nejjari C. [Diabetes and erectile dysfunction in Morocco: epidemiological study among outpatients] East Mediterr Health J Sep-Oct;14(5): French. 7

8 65. Israili ZH, Lyoussi B, Hernández-Hernández R, Velasco M. Tratamiento de pacientes hipertensos con síndrome metabólico. In: Hypertension Arterial Para el Clínico, Hernández-Hernández R, Velasco M, Armas- Padilla, Maria Jose, eds., Dinamic Signs c.a., Caracas, Venezuela 2008, pp A.Touzani, M. candito, L. Chabraoui, B. Lyoussi. Metabolic syndrome in moroccan children and adolescents. Obesity 2011 ( in press) 67. Jabeen Q, Bashir S, Lyoussi B, Gilani AH. Coriander fruit exhibits gut modulatory, blood pressure lowering and diuretic activities. J Ethnopharmacol Feb 25;122(1): Epub 2008 Dec Israili ZH, Lyoussi B. Ethnopharmacology of the plants of genus Ajuga. Pak J Pharm Sci Oct;22(4): Tahraoui A, Israili ZH, Lyoussi B. Acute and sub-chronic toxicity of a lyophilised aqueous extract of Centaurium erythraea in rodents. J Ethnopharmacol Oct 28;132(1): Epub 2010 Aug Gaamoussi F, Israili ZH, Lyoussi B. Hypoglycemic and hypolipidemic effects of an aqueous extract of Chamaerops humilis leaves in obese, hyperglycemic and hyperlipidemic Meriones shawi rats. Pak J Pharm Sci Apr;23(2): Ali El Antri a, Nadya Lachkar a, Hanane El Hajjaji a, Farah Gaamoussi b,badiaa Lyoussi b, Brahim El Bali c, Nicole Morel d, Hassan Allouchi e,mohammed Lachkar a,* Structure elucidation and vasodilator activity of methoxy flavonols from Calycotome villosa subsp. intermedia Arabian Journal of Chemistry (2010) 3, Troudi A, Bouaziz H, Soudani N, Ben Amara I, Boudawara T, Touzani H, Lyoussi B, Zeghal N. Neurotoxicity and oxidative stress induced by gibberellic acid in rats during late pregnancy and early postnatal periods: Biochemical and histological changes. Exp Toxicol Pathol Jan 73. Mediha Sefi, Hamadi Fetoui, Nadya Lachkar, AdilTahraoui, Badiaa Lyoussi, Tahia Boudawara, Najiba Zeghal Centaurium erythrea (Gentianaceae) leaf extract alleviates streptozotocin-induced oxidative stress and ß-cell damage in rat pancreas, J Ethnopharmacology, Aissaoui A, Zizi S, Israili ZH, Lyoussi B. Hypoglycemic and hypolipidemic effects of Coriandrum sativum L. in Meriones shawi rats. J Ethnopharmacol Smail Aazza 1,2*,, Badiâ Lyoussi 1, Maria G. Miguel 2 Antioxidant and anticholinesterase activities of some commercial essential oils and their major compounds Molecules Sep 7;16(9): Mharti FZ, Lyoussi B, Abdellaoui A Antibacterial activity of the essential oils of Pistacia lentiscus used in Moroccan folkloric medicine. Nat Prod Commun Oct;6(10): Smail Aazza1,2*,, Badiâ Lyoussi1, Maria G. Miguel2 Antioxidant activity of some Morrocan hydrosols Journal of Medicinal Plants Research Vol. 5(30), pp , 16 December,

9 COMMUNICATIONS 1. Lyoussi, B., Herbuté, S. & Baylé, J.D. ( 1984) : Le rôle de l'hypothalamus dans la réponse thyroidienne au froid. Premier Congrés Scientifique International organisé conjointement par l'association Marocaine de Neurosciences et l'association de physiologistes de France, rabat, Morocco 2. Lyoussi, B., Herbuté, S. & Baylé, J.D. (1985) : Régulation noradrénergique centrale de la réponse thyroidienne au froid. 110 ème Congrès National des Sociétés Savantes, Montpellier, France 3. Lyoussi, B., Herbuté, S. & Baylé, J.D. (1988) : Influence dez catécholamines dans la réponse thyroidienne au froid. 2ème Congrés Scientifique International organisé conjointement par l'association Marocaine de Neurosciences et l'association de physiologistes de France à Laayoune, Morocco 4. Lyoussi, B. & Crabbé, J. (1993). Effect of K + depletion on ( Na + + K + ) -ATPase in tight epithelia. International Colloque in Renal Transport.Paris, France 5. B. Lyoussi, H. Rhiouani. & A. Settaf. (1997). Diuretic effects of extracts of Herniaria glabra in rats. Pflügers Archiv 433 : R10, Belgium 6. M. Benwahhoud, A. Touzani, M. Lahrichi, B. Lyoussi. ( 1997). Effet hypoglycémiant de Suaeda fructicosa chez le rat streptozotocine. Symposium International Nutrition et Diabète, Rabat, Morocco Octobre Sous le Haut Patronage de Sa Majesté le Roi Hassan II 7. Eddouks, M., Berteloot, A., Lyoussi, B ( 1997). Régulation du transport du glucose par l'insuline et le glucose dans les tubules proximaux rénaux de lapin. Symposium International Nutrition et Diabète, Rabat, Morocco Octobre Sous le Haut Patronage de Sa Majesté le Roi Hassan II 8. L. Aarab and B. Lyoussi. Effet de la déshydratation sur les réponses hormonales du canal collecteur de la médullaire externe du rein chez un rongeur désertique, la gerboise. Congrès International de la Société de Physiologie, Prague. September A. Lotfi, B. Lyoussi, D. Chabardès. Interactions hormonales dans le canal collecteur de la médullaire externe du rat : régulation de la réponse au glucagon. Premières journées internationales de physiopathologie du diabète: Aspects moléculaires et cliniques, Hotel Menzeh Zalagh, Fès, Morocco, 19 et 20 Décembre H. Rhiouani., A. Settaf., B. Lyoussi., Y. Cherrah., M. Hassar. Actions diurétique et anti-hypertensive des saponines de Herniaria glabra chez le rat spontanément hypertendu ( SHR)Congrès de l'amec, Décembre H. Rhiouani, A. Settaf, B. Lyoussi, M.A. Lacaille-Dubois, Y. Cherrah et M. Hassar. Effets antihypertenseur et diurétique des saponines de Herniaria glabra chez le rat SHR. 5 éme Congrès de la Société Méditerranéenne de Pharmacologie Clinique, Marrakech, Maroc, Octobre Benwahhoud, M, R. Dieguez, Villalon, B. Lyoussi. (1998). Réactivité vasculaire à la vasopressine chez le rat streptozotocine : Effets de Suaeda fruticosa. Vth Congress Mediterranean Society of Clinical Pharmacology, October 13. M. Haloui, B. Lyoussi ( 1997) Effets diurétiques de la lavande et la petite Centaurée chez le rat. Colloque Intern sur substances naturelles, Avril, Meknès 14. Rhiouani,A, Lyoussi, B, Settaf, A, Cherrah, Y, Hassar, M. (1997). Toxicité aigue et chronique de Herniaria glabra chez le rat. Colloque Intern sur substances naturelles, Avril, Meknès 15. F. Lamchouri, A. settaf, Y. Cherrah, Y. Zaid, B. Lyoussi, Hassar, M. (1998). Etude comparée de l'activité antimitotique du décocté de Anabis aretoides, Haloxylon scoparium et Peganum harmala. Vth Congress Mediterranean Society of Clinical Pharmacology, October 9

10 16. B. Lyoussi, H. Rhiouani, A. Settaf., Y. Cherrah., M. Hassar. Diuretic and anti-hypertensive effects of saponins from Herniaria glabra in spontaneous hypertensive rats ( SHR) International Congress of Pharmacology, Munchen, Germany, juillet B. Lyoussi, Lotfi, A., D. Chabardès. PGE2 and carbachol induces an inhibition of camp in the glucagon sensitive cells of the rat OMCD. International Congress of Pharmacology, Munchen, Germany, juillet H. Rhiouani; A. Settaf; Y. Cherrah; M. hassar and B. Lyoussi. Anti-hypertensive effects of saponins from herniaria glabra L. in spontaneously hypertensive rats. First International Congress on Hypertension From Physiopathology to Treatment, Palais des Congrès, Fès, october H. Rhiouani; Kramp and B. Lyoussi. Diuretic effect of decoction of herniaria glabra L. in rats. First International Congress on Hypertension From Physiopathology to Treatment, Palais des Congrès, Fès, october H. Rhiouani; A. Settaf; B. Lyoussi; Y. Cherrah; F. Mansouri and M. Hassar. Acute and chronic toxicity of herniaria glabra L. First International Congress on Hypertension From Physiopathology to Treatment, Palais des Congrès, Fès, october H. Jouad, M. Eddouks, M. LaCaille DuBois, B. Lyoussi. Effect of the flavonoids extracted from Spergularia purpurea Pers. on arterial blood pressure and renal function in normotensive and spontaneously hypertensive rats. International Congress on Hypertension, octobre 1999, Fès, Morocco 22. H. Jouad, M. Eddouks, M. LaCaille DuBois, B. Lyoussi. Acute diuretic effect of the water extract of Spergularia purpurea (Caryophyllaceae)» International Congress on Hypertension, octobre 1999, Fès, Morocco 23. M. M guil, M.E. Ragala, A. Chraibi, L. Chbraoui, A. Kadiri, B. Lyoussi, Hypertendus diabetique type 2 : influence du jeune sur les paramètres biochimiques au cours du mois de Ramadan. In International Congress on Hypertension, octobre 1999, Fès, Morocco 24. M.E. Ragala, M. M guil, A. Chraibi, A. Kadiri, P. LeFèbvre, B. Lyoussi, Hypertendus diabetique type 2 : Profils hormonaux au cours du mois de Ramadan, In International Congress on Hypertension, octobre 1999, Fès, Morocco 25. M. Haloui, D. M. Zeitoun, L. Louedec, M. Philipe, J.B. Michel, B. Lyoussi. Urinary ANF interferes with the macula densa. In International Congress on Hypertension, octobre 1999, Fès, Morocco 26. M. Haloui, L. Louedec, J.B. Michel, B. Lyoussi. Comparative diuretic effect of Rosmarinus officinalis and Centaurium erythrea. In International Congress on Hypertension, octobre 1999, Fès, Morocco 27. S. El Bardai, N. Morel, M. Wibo, B. Lyoussi. Hypotensive activity of Marrubium vulgare and Foeniculum vulgare in spontaneously hypertensive rats International Congress on Hypertension, octobre 1999, Fès, Morocco M.E. Ragala, M. M guil, A. Chraibi, A. Kadiri, P. LeFèbvre, B. Lyoussi ( 2000) Influence du jeûne sur les paramètres hormonaux chez les diabétiques de type 2. 7th meeting of the Mediterranean Group of the study of Diabetes, Palais des Congrès, Marrakech, March 30, April 1, 2000 Under the High Patronage of His Majesty King Mohammed VI 29. Mguil, A. Chraibi, L. Chabraoui, M. A. Ragala, B. Lyoussi, Y. Cherrah, A. Kadiri 10

11 (2000). Etude du profil de quelques paramètres biologiques chez le diabétique de type 2 au cours du mois de Ramadan. Congrès de la Société Marocaine d Endocrinologie Tanger octobre 30. M. Mguil, A. Ragala, A. Chraibi, L. Chabraoui, A. Kadiri, Y. Cherrah, B. Lyoussi ( 2000 ). Diabète de type 2 : influence du surpoids et du jeûne sur le profil de certains paramètres biochimiques au cours du mois de Ramadan. Congrès de la Société Marocaine d Endocrinologie Tanger octobre B. Louasté, A. Chraibi, O. Sayrh, M. A. AlaouiL, B. Lyoussi, A. Kadiri ( 2000 ) Profil des anticorps antithyroïdiens dans la pathologie thyroïdienne chez le diabétique de type 1. Congrès de la Société Marocaine d Endocrinologie Tanger octobre M. Mguil, A. Mrini, Y. Cherrah, B. Lyoussi, S. Fellat. ( 2000 ) Influence du jeûne sur l évolution du profil lipidique chez les sujets sains en surpoids ou obèses. Congrès de la Société Marocaine d Endocrinologie Tanger octobre M. A Ragala, M.Mguil, A. Chraibi, A. Kadiri, P. Lefebvre, B. Lyoussi ( 2000). La leptine, l insuline, le C- peptide et l IGF1 chez les diabétiques de type 2 au cours du mois de Ramadan (3 ème prix poster Laboratoire Servier). Congrès de la Société Marocaine d Endocrinologie Tanger octobre J. Hilali et B. Lyoussi ( 2000). Hypoglycemic effects of Ajuga iva in streptozotocin rats, Congrès de la SMEDIAN, Tanger 35. B.Lyoussi, M; Haloui, D. Messika-Zettoun, L. Louedec, M ; Philippe, J.B. Michel. ( 2000). Urinary ANP interferes with the macula densa. Deuxième Congrès de Génétique et Biologie Moléculaire, Novembre, Fès 36. B. Lyoussi, S. EL Bardai, M. Wibo, Morel, N. Experimental therapeutic efficacy of Moroccan medicinal plants used in the treatment of diabetes and cardiovascular diseases 1st International Congress on traditional medicine & materia medica, Tehran, Iran 6, 9 November B. Lyoussi, S. EL Bardai, M. Wibo, Morel, N. Hypotensive activity of Foeniculum vulgare and Marrubium vulgare in SHR rats. 68 Congrès Société de Physiologie, Fac Med Liège,Belgique, Septembre Maghrani, M et Lyoussi, B. (2001) : Etude des effets rébaux de l'aortie chez le rat uninephrectomisé. Congrès de la Société Marocaine des Maladies Rénales 39. J. Hilali, B. Lyoussi (2001): Exploration des paramètres de la fonction rénale chez le rat nephrectomisé au 5/6 et nephrotoxique : influence de l'extrait d Ajuga iva. Congrès National de la Société Marocaine de Néphrologie 40. H. Jouad, M. LaCaille DuBois, B. Lyoussi, M. Eddouks ( 2001) Effects of the flavonoids extracted from of Spergularia purpurea pers. On arterial blood pressure and renal function in normal and hypertensive rats. Premier Congrès de AMPEPM, Plantes Médicinales : Biologie et Santé, Kénitra 41. EL Bardai,S, Lyoussi, B, M. Wibo, Morel, N( 2001). Comparative effects of calcium antagonists and marrubium vulgare on cardiovascular remodeling in SHR rats. Pflueger Arch, November congrès de la Société Belge de pharmacologie, leuven, Belgique 42. B. Lyoussi, S. EL Bardai, M. Wibo, Morel, N. (2001) Effects of chronic treatment of marrubium vulgare in comparison with the calcium antagonist amlodipine in spontaneously hypertensive rats, PP 46, Experimental Biology, FASEB, Orlando, USA, March 31, April 4 11

12 43. B. Lyoussi, S. EL Bardai, M. Wibo, Morel, N (2001) Amlodipine, Marrubine and cardiovascular remodeling, European Federation of Pharmacology, Lyon, France, July, 6-9, J. El Hilaly, B.Lyoussi. (2001) Hypoglycemic effects of Ajuga Iva in streptozotocin diabetic rats, 3 ème congrès de la SMEDIAN, Agadir, Premier prix des laboratoires Servier, Septembre 45. A. Miloud, A. Mounaim, Y. Riouch, A. Chraibi, B. Lyoussi. ( 2001). HTA et facteurs de risque cardiovasculaire chez la femme en milieu rural. Enquête épidémiologique 3 ème congrès de la SMEDIAN, Agadir, prix abonnement Revue. 46. L. Bouddine & B. Lyoussi. Hypoglycemic effects of argania spinosa in type II diabetic Meriones Schawi Congrès SMEDIAN, Agadir, Septembre M. Moumouh, M. A. Ragala, A. Chraibi, B. Lyoussi ( 2001)..Etude du profil biologique chez le sujet diabétique de type 2.Congrès national de la SMEDIAN. Agadir septembre J. Hilali, B. Lyoussi (2001): Exploration des paramètres de la fonction rénale chez le rat nephrectomisé au 5/6 et nephrotoxique : influence de l'extrait d Ajuga iva. Congrès National de la Société Marocaine de Néphrologie, Casablanca B. Lyoussi. Vasorelaxant activity of diterpenes from Marrubium vulgare Symposium International RPMA 2002, Fac Med et Pharm, Rabat, 2-4 Mai J. El Hilaly & B. Lyoussi. Antihypertensive and vasodilatory effect of Ajuga iva in SHR-SP and wistar rats, Symposium International RPMA 2002, Fac Med et Pharm, Rabat, 2-4 Mai J. El Hilaly, N. Morel, M. Wibo & B. Lyoussi. Hypotensive activity of aqueous extract of Ajuga iva in SHR- SP, Symposium International RPMA 2002, Fac Med et Pharm, Rabat, 2-4 Mai El Hilaly. J and B. Lyoussi ( 2002). Acute toxicity and chronic toxicological studies on biochemical and haematological parameters carried out in mice and rats., Symposium International RPMA 2002, Fac Med et Pharm, Rabat, 2-4 Mai El Bardai, S., N. Morel, M. Wibo, B.Lyoussi. Chronic treatment by Marrubium vulgare improved the impaired endothelial function in SHR., Symposium International RPMA 2002, Fac Med et Pharm, Rabat, 2-4 Mai El Bardai, S., M. Wibo, N. Morel, J. Quetin- Leclercq, B.Lyoussi (2002).Identification of diterpenes involved in the vasorelaxant activity of Marrubium vulgare Second International Pan Arab Congress of Pharmacology, 5-8 September 2002, Palais des Congrès, Fès 55. El Hilaly. J, M. Wibo, N. Morel, B.Lyoussi ( 2002) Pharmacological evidence of antihypertensive activity of Ajuga iva in SHR SP rats Second International Pan Arab Congress of Pharmacology, 5-8 September 2002, Palais des Congrès, Fès 56. El Hilaly. J and B. Lyoussi ( 2002). Hypoglycaemic effects of lyophilised aqueous extract of Ajuga iva in normal and streptozotocin diabetic rats Second International Pan Arab Congress of Pharmacology, 5-8 September 2002, Palais des Congrès, Fès 57. El Hilaly. J and B. Lyoussi ( 2002). Experimental toxicity of Ajuga iva extracts Second International Pan Arab Congress of Pharmacology, 5-8 September 2002, Palais des Congrès, Fès 12

13 58.Tahiri Alaoui.G, El antri. A, Lachkar, B. Lyoussi (2002).Hypoglycemic effects of flavonoids from Calycotome villosa in streptozotocin induced diabetic rats Second International Pan Arab Congress of Pharmacology, 5-8 September 2002, Palais des Congrès, Fès 59. Gaamoussi, F, B. Lyoussi ( 2002). Hypoglycemic effects of extracts of chamaerops humilis in diabetic type II Meriones. Second International Pan Arab Congress of Pharmacology, 5-8 September 2002, Palais des Congrès, Fès 60. Tahiri Alaoui. G and B. Lyoussi ( 2002 ) Experimental diuretic effects of Corrigeola telefifolia in Psammomys obesus Second International Pan Arab Congress of Pharmacology, 5-8 September 2002, Palais des Congrès, Fès 61. S. Lahlou, N. Morel, M. Wibo and B. Lyoussi (2002). Vasorelaxant activity of carum carvi extract in rat. Second International Pan Arab Congress of Pharmacology, 5-8 September 2002, Palais des Congrès, Fès 62. El Bardai, S., M. Wibo, N. Morel, J. Quetin- Leclercq and B.Lyoussi (2002) Identification of diterpenes involved in the vasorelaxant activity of Marrubium vulgare. Second International Pan Arab Congress of Pharmacology, 5-8 September 2002, Palais des Congrès, Fès 63. S. EL Bardai, N. Morel, M; Wibo and B. Lyoussi (2002) Comparative study between the antihypertensive activity of Marrubium vulgare and the calcium antagonist amlodipine in SHR. Second International Pan Arab Congress of Pharmacology, 5-8 September 2002, Palais des Congrès, Fès 64. El Hilaly. J, M. Wibo, N. Morel and B. Lyoussi (2002). Vasodilatory effect of aqueous extract Ajuga iva in rat Second International Pan Arab Congress of Pharmacology, 5-8 September 2002, Palais des Congrès, Fès 65. J. ElHilaly, M.Wibo, N. Morel and B.Lyoussi (2002). Antihypertensive effects of aqueous extract of Ajuga iva in thoracic aorta from stroke-prone hypertensive rats. Second International Pan Arab Congress of Pharmacology, 5-8 September 2002, Palais des Congrès, Fès 66. S. EL Bardai, N. Morel, M; Wibo and B. Lyoussi (2002). Pharmacological evidence of hypotensive activity of Marrubium vulgare and Foeniculum vulgare in spontaneously hypertensive rat Second International Pan Arab Congress of Pharmacology, 5-8 September 2002, Palais des Congrès, Fès 67. L. Bouddine & B. Lyoussi. (2002). Hypoglycemic effect of argan oil in diabetic Meriones Shawi. Second International Pan Arab Congress of Pharmacology, 5-8 September 2002, Palais des Congrès, Fès 68. Rhrich-Haddout F., Kassar L., Lyoussi B., Horvat J-C (2002). Alpha-motoneurons of the injured cervical spinal cord of adult rat can reinnervate the biceps brachii muscle by regenerating axons through peripheral nerve bridges: combined ultrastructural and retrograde axonal tracing study 69. Ahmed Benyassi, Jack Falcon, Christian Schwartz, Steven L. Coon, Badia Lyoussi and David C. Klein. (2002). An exception to the rule : light increases the activity of the melatonin rhythm enzym in the trout retina 70. Emery E., Rhrich-Haddout F., Kassar L., Lyoussi B., Tadié M., Horvat J-C ( 2002) Motoneurons of the adult marmoset can grow axons and reform motor endplates through a peripheral nerve bridge joining the lacally injured cervical spinal cord to the denervated biceps brachii muscle 71. S. El Bardai, J. Leclercq, M. Wibo, N. Morel and B. Lyoussi ( 2003) Characterization of marrubenol as an L-type calcium channel blocker. First Mediterranean Forum of kidney Diseases 30, 31 January 1 February 72. M. Ibn khayat, P. Zatta, M. Hilali & B. Lyoussi ( 2003). Aluminum deposition in target organs after acute and chronic administration in experimental animals : effects of aluminum speciation. First Mediterranean Forum of kidney Diseases 30, 31 January 1 February 73. S. El Bardai, J. Leclercq, M. Wibo, N. Morel and B. Lyoussi ( 2003) Characterization of marrubenol as an L-type calcium channel blocker. First Mediterranean Forum of kidney Diseases 30, 31 January 1 February 13

14 74. M.E. Ragala, M. M guil, K. Cherkaoui Tangi, A. Aissaoui, M. Moumouh, A. Chraibi, A. Zafar H. Israili, B. Lyoussi ( 2004) gender specific leptinemia and its relationship with other indices of the metabolic syndrome, Palais des Congrès, Marrakech, May 19 23, 2004 Under the High Patronage of His Majesty King Mohammed VI 75. B. Lyoussi, M.E. Ragala, A. Chraibi, S. Mantovani (2004) Nutritional supplement and hypocaloric diet for weight loss : a randomized, double blind trial, Palais des Congrès, Marrakech, May 19 23, Under the High Patronage of His Majesty King Mohammed VI 76. B. Lyoussi, S. El Bardai, M. Wibo, M.C. Hamaide, J. Leclercq, N. Morel ( 2004) Characterization of marrubenol, a diterpene extracted from Marrubium vulgare as an L-type calcium channel blocker. 4 th Congress of the Federation of the European Pharmacological Societies ( EPHAR) July B. Lyoussi, M.E. Ragala, A. Chraibi, S. Mantovani (2004) Nutritional supplement and hypocaloric diet for weight loss : a randomized, double blind trial, Palais des Congrès, Marrakech, May 19 23, Under the High Patronage of His Majesty King Mohammed VI 78. B. Lyoussi, S. El Bardai, M. Wibo, M.C. Hamaide, J. Leclercq, N. Morel ( 2004) Characterization of marrubenol, a diterpene extracted from Marrubium vulgare as an L-type calcium channel blocker. 4 th Congress of the Federation of the European Pharmacological Societies ( EPHAR) July B. Lyoussi, S. El Bardai, M. Wibo, N. Morel ( 2005) Comparative study between the antihypertensive activity of Marrubium vulgare and the calcium antagonist amlodipine in SHR rats 5 th Conference of the PanArab Hypertension Society, September 14-17, 2005, Tunis 80. S. El Bardai, M. Wibo, M.C. Hamaide, J. Leclercq, N. Morel, B. Lyoussi (2006) Vasorelaxant activity of marrubium vulgare and of the dihydropyridine calcium antagonist amlodipine in SHR rats The future role of natural products in health care 2ème symposium international sur les plantes aromatiques et médicinales, Marrakech, Septembre Tahraoui.a, Elhilaly, J and B. Lyoussi (2006) Ethnopharmacological survey of plants used in the traditional treatment of hypertension and diabetes in south eastern morocco ( Errachidia province) 2ème symposium international sur les plantes aromatiques et médicinales, Marrakech, Septembre S. Lahlou, A. Tahraoui, Z. Israili, B. Lyoussi ( 2006) Diuretic activity of the aqueous extracts of Carum carvi and Tanacetum vulgare in rats 2ème symposium international sur les plantes aromatiques et médicinales, Marrakech, Septembre S. Lahlou, Morel, N, Bacceli C, Mavar, H, Haddad, M, Quetin Leclercq J, B. Lyoussi ( 2006) Vasorelaxant activity of flavonoid extracted from Tanacetum vulgare 2ème symposium international sur les plantes aromatiques et médicinales, Marrakech, Septembre J. ElHilaly, H. Rhiouani, B. Lyoussi ( 2006) Toxicological study of Herniaria glabrain experimental animals / biochemical, haematological and histopathological consequences 2ème symposium international sur les plantes aromatiques et médicinales, Marrakech, Septembre J. ElHilaly, M. Wibo, J. Leclercq, N. Morel, B. Lyoussi ( 2006) Toxicological, pharmacological and chemical investigations of Ajuga iva 2ème symposium international sur les plantes aromatiques et médicinales, Marrakech, Septembre M. M guil, M. A. Ragala, L. El Guessabi, S. Fellat, A. Chraibi, L. Chebraoui, Z. H. Israili, and B. Lyoussi (2006) 14

15 Effect of Ramadan fasting on some clinical and metabolic parameters, and diabetic control in patients with type 2 diabetes mellitus 87. K. Cherkaoui-Tangi et B. Lyoussi Etude épidémiologique et biologique chez le diabétique de type 2 dans deux sites cibles à la région de la wilaya de Fès -Boulemane 88. Ragala MA, Chraibi A, S. Mantovani Lyoussi, B Nutritional supplement and hypocaloric diet for weight loss 89. Lyoussi, B, Ragala MA, M guil M, Chraibi A, Zafar H. Israili Gender specific leptinemia and indices of metabolic syndrome 90. M.Moumouh, M.A. Ragala, B.Lyoussi ( 2006) Effet de la classe thérapeutique des antidiabétiques oraux sur le profil biologique chez le diabétique type A.F.Aissaoui, B. Lyoussi ( 2006) La dyslipidémie chez les diabétiques type 2 et pathologies associées 92. Jaouad El-Hilaly et coll Phytochemical, toxicological and pharmacological investigations on Ajuga iva in experimental animals 93. B. Lyoussi et coll (2006) Comparative study of the antihypertensive activity of Marrubium vulgare and of the dihydropyridine calcium antagonist amlodipine in spontaneously hypertensive rat: Characterisation of marrubenol, a diterpene extracted from Marrubium vulgare, as an L-type calcium channel blocker. 94. C Abderahim Aissaoui et coll ( 2006) Continuous intravenous perfusion of aqueous extract of Coriandrum sativum L ( Apiaceae) in rats : Renal effects 95. S. Zizi, B. Lyoussi, M. Akrim, H. Ramdani ( 2006) L'hépatite C et les manifestations autoimmunes 96. Qaiser Jabeen, Samra Bashir, Anwar H Gilani, Badiaa Lyoussi ( 2006) Studies on cardiovascular and diuretic activities of the aqueous-methanol extract of Coriandrum sativum. Dept. Biological and Biomedical Sciences, Aga Khan University Medical College, Karachi-74800, Pakistan and Laboratoire de Physiologie Pharmacologie & Santé environnementale, Faculté des Sciences Dhar-El mehraz, Fès, International symposium, Fez, November, Youness El Achhab, Chakib Nejjari, Badiaa Lyoussi, Philippe Boutin, Mohamed Chikri ( 2006) Type 2 diabetes in Morocco: focus on lipids and cardiovascular risk, international symposium, Fez, November A. Touzani, L. Chabraoui, J. Drai, A. Gaouzi, Z. H. Israili, and B. Lyoussi ( 2006) Relationship between hyperleptinemia and some cardiovascular risk factors associated with the metabolic syndrome in obese children and adolescents 99. Sanaa Lahlou, Adil Tahraoui, Zafar Israili, Badiaa Lyoussi ( 2006) Diuretic activity of the aqueous extracts of Carum carvi and Tanacetum vulgare in normal rats, international symposium on cardiovascular risk factors, Fez, November Ali Kaddafi, Kacimi Alaoui Hajar, D.Couissi, M.Bourhim & Badiâa Lyoussi (2006) Étude de l effet diurétique et hypotenseur de Centaurium Erythreae international symposium on cardiovascular risk factors, Fez, November K. Cherkaoui-Tangi, M. Lachkar, M. Wibo, N. Morel, A.Gilani, B. Lyoussi ( 2006) Cardiovascular effects of a chrysin glucoside from Calycotome Villosa subsp. Intermedia, Diuretic,hypotensive and vasodilator effect on anaesthetized rats 15

16 International symposium on cardiovascular risk factors, Fez, November K.Cherkaoui-Tangi, B.Lyoussi ( 2006) Pharmacological screening of medicinal plants used as antihypertensive in Sefrou region International symposium on cardiovascular risk factors, Fez, November N.Lachkar, K.Cherkaoui-Tangi, D. Couissi, M. Bourhim, B.Lyoussi ( 2006) Etude épidémiologique du diabète sucré dans larégion Fès - Boulemane International symposium on cardiovascular risk factors, Fez, November R.Badra, K.Cherkaoui-Tangi, D. Couissi, M. Bourhim & B.Lyoussi ( 2006) Etude de l effet diurétique, toxicologique et antihypertenseur d Ammodaucus leucotrichus. L et d Ononis natrix L. Chez différents modèles animaux International symposium on cardiovascular risk factors, Fez, November J. Laamech, K. Cherkaoui-Tangi, A. Laamarti, B. Lyoussi ( 2006) Effet toxicologique, anatomopathologique et hypotenseur de la Berberis vulgaris L. chez la souris et le lapin normotensif International symposium on cardiovascular risk factors, Fez, November Lahlou S, Morel N., Bacceli C., Mavar H., Auclair G., Haddad M., Quetin-Leclercq, Lyoussi B ( 2006) Vasorelaxant activity of flavonoid extracted from Tanacetum vulgare International symposium on cardiovascular risk factors, Fez, November N.Lachkar, K.Cherkaoui-Tangi, A.Tahouri, D.Couissi, M. Bourhim, B.Lyoussi ( 2006) Etude de l effet hypoglycémiant d Ammadaucus Leucotrichus chez le rat streptozotocine International symposium on cardiovascular risk factors, Fez, November Tahraoui A, Lyoussi B. ( 2006) Acute and chronic toxicological studies of Centaurium Erythreae in experimental animals International symposium on cardiovascular risk factors, Fez, November A.Touzani., N.Bennani., B.Lyoussi., N. Benchrifa., L.Chabraoui., M.Lahrichi., A.Balafrej. Association dysthyroidies auto-immunes et diabète de type 1 chez les Enfants et les jeunes patients : éude prospective sur 446 cas. Congrés Maghrébin de Pédiatrie, 8-9 Avril, Hammamet- Tunisie, Mai A.Touzani., A.Gaouzi., B.Lyoussi., H.Bahaymed.,L.Chabraoui., M.Lahrichi.Contribution à l étude des variations du profil biologique chez l enfant Obèse. Congrès Maghrébin de Pédiatrie.8-9 Avril, Hammamet- Tunisie A.Touzani., M.Candito.,L.Chabraoui.,A.Balafrej., B.Lyoussi., M.Lahrichi.Etude de l homocystéinémie chez les enfants et les jeunes patients diabétiques de type 1. 5 èmes Journées nationale de biologie clinique octobre, Rabat, A.Touzani.,A.Gaouzi.,B.Lyoussi.,H.Bahaymed.,M.Lahrichi.,L.Chabraoui. Evaluation des perturbations du profil métabolique chez l enfant obèse : Impact du régime nutritionnel. Congrès smedian, Fès Novembre A.Touzani.,M.Candito.,B.Lyoussi.,A.Gaouzi.,L.Chabraoui.L hyperhomocystéinémie et les facteurs de risque du syndrome métabolique chez l enfant obèse. XII Journées de la société marocaine de chimie clinique, Rabat Mars,

17 114. K. Cherkaoui-Tangi, M. Lachkar, M. Wibo, N. Morel, A.Gilani, B. Lyoussi ( 2007) Pharmacological studies on hypotensive, diuretic and vasodilator activities Cardiovascular effects of a chrysin glucoside from Calycotome Villosa subsp. Intermedia in anaesthetized rats International symposium sur le medicament de phytothérapie et plantes médicinales, Constantine, Mars Lahlou S., Morel N., Bacceli C., Mavar H., Haddad M., Quetin-Leclercq J and Lyoussi B ( 2007) Vasodilatory effect of flavonoid extracted from tanacetum vulgare. International symposium sur le medicament de phytothérapie et plantes médicinales, Constantine, Mars Qaiser Jabeen Samra Bashir, Anwar H. Gilani, Badiaa Lyoussi, ( 2007) Studies on cardiovascular and diuretic activities of coriander sativum. International symposium sur le medicament de phytothérapie et plantes médicinales, Constantine, Mars Jaouad El-Hilaly,M. Wibo, J. Leclercq, N. Morel and B. Lyoussi ( 2007) Toxicological and pharmacological properties of Ajuga iva in experimental animals models International symposium sur le medicament de phytothérapie et plantes médicinales, Constantine, Mars M.Mguil ; B.Lyoussi ; A. Chraibi (CHU Ibn Sina de Rabat, Faculté des Sciences de Fès) Evaluation de paramètres clinico-biologiques au cours du Ramadan 2ème journée d Endocrinologie, Diabétologie Ibn Sina Rabat, Samedi 08 septembre F. Latrache, A.El Antri, K. Cherkaoui-Tangi, B. Lyoussi, B. El Bali, N. Morel, H. Allouchi, M. Lachkar ( 2007) Flavonoids from Calycotome Villosa subsp. Intermedia : isolation, X ray Structure determination and vasodilator activity. Congrès International sur les plantes médicinales et aromatiques, Fès, Mars K. Cherkaoui-Tangi. M. Wibo, N. Morel, B. Lyoussi (2007) Antidiabetic and hypotensive effects of Calycotome villosa Subsp. Intermedia seeds in Meriones Shawi rats The International Conference: Biotechnology and Environmental Science, November 19-21, Hamid Rhiouani, Jaouad El-Hilaly, Zafar H. Israili & Badiâa Lyoussi Acute and sub-chronic toxicity of an aqueous extract of the leaves of Herniaria glabra in rodents The International Conference: Biotechnology and Environmental Science, November 19-21, Tahraoui A, Lyoussi B.(2007) Acute and chronic toxicological studies of Centaurium erythreae in experimental animals The International Conference: Biotechnology and Environmental Science, November 19-21, Abderahim Aissaoui, Jaouad El-Hilaly, Zafar H. Israili, Badiˆaa Lyoussi ( 2007) Acute diuretic effect of continuous intravenous infusion of an aqueous extract of Coriandrum sativum L. in anesthetized rats. The International Conference: Biotechnology and Environmental Science, November 19-21, EL ARABI Ilham and LYOUSSI Badiaa ( 2007) Adaptatives strategies of plants to abiotic stress : Contribution to the study of environmental signals transduction : some agonists and antagonists effects on stomatal responses : Transduction of signlas ABA and calcium in guard cells of Vicia faba, Commelina communis and Arabidopsis thaliana. The International Conference: Biotechnology and Environmental Science, November 19-21, Fatima Lamchouri, Mustafa Zemzami, Akino Jossang, Abdellatif Settaf and Badiaa Lyoussi (2007) Antiproliferative constituents from Zygophyllaceae plants The International Conference: Biotechnology and Environmental Science, November 19-21, Lyoussi B, El-Bardai S, Wibo M, Hamaide MC, Quetin-Leclercq J, Morel N ( 2007) 17

18 Comparative study of the antihypertensive activity of Marrubium vulgare and of the dihydropyridine calcium antagonist amlodipine in spontaneously hypertensive rat: Characterisation of marrubenol, a diterpene extracted from Marrubium vulgare, as an L-type calcium channel blocker. The International Conference: Biotechnology and Environmental Science, November 19-21, Sanaa Lahlou, Khadija Cherkaoui Tangi, Nicole Morel, Badiaâ Lyoussi (2007) Cardiovascular effects of Tanacetum vulgare L. leaf extract: in vitro : pharmacological study The International Conference: Biotechnology and Environmental Science, November 19-21, A. Chouiakh, N Lachkar, K Cherkaoui, B Lyoussi ( 2007) Diuretic and hypotensive effect of Punica granatum in experimental animals The International Conference: Biotechnology and Environmental Science, November 19-21, Y. Jardioui, N. Lachkar, K. Cherkaoui, B.Lyoussi (2007) Diuretic and hypotensive effect of cucurbita pepo in experimental animals The International Conference: Biotechnology and Environmental Science, November 19-21, K. Cherkaoui-Tangi; J. El-Hilaly; A.H. Gilani ; B. Lyoussi (2007) Ethnobotanical survey and pharmacological screening of medicinal plants used as antihypertensive in Sefrou province (Middle North of Morocco : Benefits and challenges) The International Conference: Biotechnology and Environmental Science, November 19-21, Y. Jardioui, N. Lachkar, K. Cherkaoui-Tangi, B.Lyoussi (2007) Etude de l effet diurétique et hypotenseur des graines de Cucurbita pepo chez le rat Wistar et le lapin normotendu. The International Conference: Biotechnology and Environmental Science, November 19-21, Kaddafi Ali, Kacimi Alaoui Hajar, B.Lyoussi ( 2007) Etude de l effet diurétique et hypotensif de Centaurium erythræa Rafn chez le rat et le lapin The International Conference: Biotechnology and Environmental Science, November 19-21, M.Moumouh, M.A. Ragala, B. Lyoussi (2007) Effect of supplementation of traditional medicinal plants on blood glucose in non insulin dependent diabetics from Fez Boulemane region The International Conference: Biotechnology and Environmental Science, November 19-21, Adil Tahraoui and Badiâa lyoussi (2007) Hypoglycaemic effect of the lyophilised aqueous extract of Erythrea centaurium in normal and streptozotocin diabetic rats. The International Conference: Biotechnology and Environmental Science, November 19-21, N. Lachkar, K. Cherkaoui Tangi, B.Lyoussi (2007) Hypoglycemic and hypolipidemic effect of Ammadaucus Leucotricus L. in normal and streptozotocin induced diabetic rats. The International Conference: Biotechnology and Environmental Science, November 19-21, Farah Gaamoussi, ZafarH.Israili and Badiâa Lyoussi (2007) Hypoglycaemic effect of Chamaerops HUMILIS IN Meriones shawi rats The International Conference: Biotechnology and Environmental Science, November 19-21, K. Cherkaoui-Tangi, M. Lachkar, M. Wibo, N. Morel, A.H. Gilani, B. Lyoussi (2007) Pharmacological studies on hypotensive, diuretic and vasodilator activities of chrysin glucoside from Calycotome villosa in rats The International Conference: Biotechnology and Environmental Science, November 19-21, Jawhar Laamech, Khadija Cherkaoui Tangi, Afaf Laamarti, Badiaâ Lyoussi (2007) Toxicological, anatomopathological and hypotensive investigations on Berberis vulgaris in experimental animals The International Conference: Biotechnology and Environmental Science, November 19-21,

19 139. Lahlou S., Morel N., Bacceli C., Mavar H., Haddad M., Quetin-Leclercq J and Lyoussi B (2007) Vasodilatory effect of flavonoid extracted from Tanacetum vulgare The International Conference: Biotechnology and Environmental Science, November 19-21, Youness El Achhab, Nerjjari, Lyoussi, Chikri.(2008) The Association of ENPP1K121Q Polymorphism with Type 2 Diabetes and Obesity in the Moroccan Population. SRO5, Fez, Morocco 141. Asmae Touzani, Chabraoui, Zafar, Lyoussi (2008) Adipocytokines and Some Cardiometabolic Factors Associated with Obesity in Children and adolescents. SRO5, Fez, Morocco 142. Sanaa Lahlou, N. Morel, J. Leclercq, B.Lyoussi.(2008) Phytochemical, Pharmacological and Toxicological Studies of Tanacetum Vulgare And Carum Carvi, Two Plants Used in the Traditional Treatment of Hypertension in Morocco. SRO5 conference, Octobre A Tahraoui, B.Lyoussi.(2008) Acute and Chronic Toxicological Studies and Hypoglycemic Effect of an Aqueous Extract of Centaurium Erythreae Whole Plant in Experimental Animals. SRO5 conference, October Khadija Cherkaoui-Tangi, N. Morel, B.Lyoussi.(2008) Pharmacological Studies on Hypotensive, Diuretic and Vasodilator Activities of Chrysin Glucoside from Calycotome Villosa in Rats. SRO5 conference, October Farah Gaamoussi, Zafar, B.Lyoussi (2008) Hypoglycemic and Hypolipidemic Effects of An Aqueous Extract of Chamaerops Humilis Leaves in Obese, Hyperglycemic Meriones Shawi Rats. SRO5 conference, October M. M'guil, Chraibi, Chabraoui, Zafar, Lyoussi (2008) Is Ramadan Fasting Safe in Type 2 Diabetic Patients in View of the Lack of Significant Effect of Fasting on Clinical and Biochemical Parameters, Blood Pressure, and Glycemic Control? SRO5 conference, October Fatima Aguiri, C.Nejjari, B.Lyoussi. (2008) Study of Behavioural Risk Factors for Cancers : Nutrition, Tobacco, Alcohol in the Fez-Sefrou Region. SRO5 conference, October Youness Jardioui, Cherkaoui, B.Lyoussi (2008) Diuretic and Hypotensive Effect of Cucurbita Pepo in Experimental Animals. SRO5 conference, October Jawhar Laamech, Lamarti, B.Lyoussi (2008) Toxicological, Anatomopathological and Hypotensive Investigations of BerberisVulgaris in Experimental Animals. SRO5 conference, October Azdine Chouiakh, K. Cherkaoui, B.Lyoussi (2008) Diuretic, Hypotenive and Antihyperglycemiant Effect of Punica Granatum in Exprimental Animals.. SRO5 conference, October Sanaa Lahlou, Zafar, B.Lyoussi. (2008) Acute and Chronic Toxicity of a Lyophilised Aqueous Extract of Tanacetum Vulgare Leaves in Rodents. SRO5 Satellite Conf. MEDICINE AND PHARMACOLGY Oct Hajar Manyani, A. Abidi, B.Lyoussi (2008) Residues of the Organochlorinated Pesticides in Pasteurized Milk and the Milk of Farm of the Area of Fez- Boulmane 2èmes journées internationals de toxicology, 3-4 Décembre 2008, Alger 19

20 153. A.touzani, Drai, Gaouzi, Lyoussi.B, Lahrichi, Chabraoui.L (2008) Marqueurs biologiques et profil métabolique chez l enfant obèse. 8èmes Journées nationales de Biologie Cliniqiue (2008) Hôtel Jnane Palace, Avril A.touzani, Drai, Gaouzi, Lyoussi.B, Lahrichi, Chabraoui.L (2008) Relation entre l hyperleptinémie et les facteurs de risque cardiovasculaire associé au syndrome métabolique chez l enfant et l adolescent obèse 8èmes Journées nationales de Biologie Cliniqiue (2008) Hôtel Jnane Palace, Avril Khadija Cherkaoui, zafar, B.Lyoussi (2008) Ethnobotanical Survey and Pharmacological Screening of Medicinal Plants Used As Antihypertensive in Sefrou Province (Middle North Of Morocco): Benefits and Challenges.. SRO5 conference, October Fatima Lamchouri, B. Lyoussi (2008) Antibacterial and Antifungal Activity of Extracts of Haloxylon Scoparium, an Ethnomedicinal Moroccan Plant. SRO5 conference, October Latifa Doudach, Y. Cherrah, B.Lyoussi (2008) Study of Anti Bacterial Activity and Evaluation of the Increased Biological Impact of the Administration of the Extract of Mesembryanthemum Nodiflorum. SRO5 conference, Fez, Morocco, October H, Rhiouani, J. ElHilaly, Zafar, B.Lyoussi (2008) Acute and Sub-Chronic Toxicity of an Aqueous Extract of the Leaves of Herniaria Glabra in Rodents. SRO5 conference, Fez, Morocco, October Mounia Moumouh, B. Lyoussi (2008) Effect of Supplementation of Traditional Medicinal Plants on Blood Glucose in Non Insulin Dependent Diabetics from Fez Boulemane Region.. SRO5 conference, Fez, Morocco, October Nadia Lachkar, K. Cherkaoui, B.Lyoussi. (2008) Hypoglycemic and Hypolipidemic Effect Of ammadaucus Leucotricus.L in Normal and Streptozotocin Induced Diabetic Rats. SRO5 conference, Fez, Morocco, October Jawhar Laamech, B.Lyoussi (2008) Renal Markers and Toxic Metals in Children and Adolescents from Rural, Urban and Industrial Area. SRO5 conference, Fez, Morocco, October Sanae Masmoudi, B.Lyoussi, Bouklouze (2008) A Comparative Study of the Analytical Method Validation of Albendazole Using UV Spectrophotometry: The Classical Procedure Vs The New Procedure (AccuracyProfile). SRO5 conference, Fez, Morocco, October Hajar Manyani, Abidi, B.Lyoussi (2008) Residues of the Organochlorinated Pesticides in Pasteurized Milk and the Milk of Farm of the Area of Fez- Boulmane. SRO5 Conference, Fez, Morocco, October B. Lyoussi (2008) Sources of exposure, geographical patterns and time trends : Exposure to elements in children and women Workpackage leader : partner 33 (PPSE), Morocco International meeting of European Project Phime, Prague, Jawhar Laamech, Khadija Cherkaoui Tangi, Afaf Lamarti and Badiaa Lyoussi (2009) Scientific valorisation of a Moroccan medicinal plant : toxicological and pharmacological effect of lyophilized extract of Berberis vulgaris L. International conference on medicinal and aromatic plants, Ifrane, Morocco, September