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1 Impact of music intervention technique in the context of Alzheimer s disease Stéphane GUETIN- Ph-D, MT Paris Descartes University, Paris 5 Neurology department, Inserm U1056, CHRU Montpellier 1

2 INTRODUCTION Many studies have underlined the usefulness of receptive music therapy technique in AD [1-2] The principal factors for success identified so far with respect to music therapy sessions are : Musical choice by the patients Use instrumental or vocal music 20 to 60 minutes in a relaxed position CHRU and have developed a software program to standardize this technique 2 Guétin [1]nouvelle Sherratt technique K et al. Music interventions for people with dementia: ofdes the douleurs literature. Aging Ment S, Giniès P, Eledjam JJ. Une contrôlée de musicothérapie dans la prise aenreview charge Healthet2004; 8: ; 18: viscérales aiguës et chroniques. Douleur Analgésie [2] Vink et al. Cochrane Data Base

3 INTERVENTION Simplified musical preferences questionnaire Choice of music depending on the patient s tastes and cultural background 20 to 60 minutes, earphones and an eye mask Use of the «U» séquence [1] [1] Guétin S, et al. Assessment and standardisation of a new music therapy technique in the management of pain: The "Ubased" system. Music & Medicine

4 Cliquez pour modifier le style du «U» SEQUENCE S, et al. Assessment and standardisation of a new music therapy technique in the management of pain: The "U-based" system. Music & Medicine Guétin 4

5 Cliquez pour modifier le style du «U» SEQUENCE S, et al. Assessment and standardisation of a new music therapy technique in the management of pain: The "U-based" system. Music & Medicine Guétin 5

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7 AIMS OF THE STUDY Principal aim : To assess the effect of this music intervention on anxiety Secondary aims : Effect on depression Maintenance of this effect (2 months after) 7

8 METHODS Type of study : Single-Blind, Randomized, Controlled Trial Approved by an ethics committee (CCP) Trial registration: Clinical trials NCT Design study : 2 groups of institutionalized patients Control group : Standard care (n=15) Experimental group : Standard care + Music Intervention (n=15) 8

9 ASSESSMENT CRITERION Primary study end-point : Anxiety Hamilton Scale Secondary study end-point : Depression Geriatric Depression Scale (GDS) Study Flow Chart 9

10 RESULTS (1) 10

11 RESULTS (2) * 11

12 Clinical Journal of Pain

13 ASSESSMENT CRITERION Primary study end-point : VAS Pain D0, D5, D10, D60, D90 Secondary study end-point : Consumption of anxiolytics and antidepressants D0, D5, D10, D60, D90 13

14 RESULTS (1) 14

15 RESULTS (2) Significant reduction in the consumption of anxiolytics P<0,01 ** * Music Control 15

16 RESULTS (3) Reduction in the consumption of antidepressants P<0,01 P<0,01 * ** * Music Control 16

17 ILLUSTRATION - Department of NeurologyCHRU Montpellier Hospital 17

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23 Cliquez pour modifier le style du AWARDS Nominated for the "Victoires de la Medicine" in the category "Innovation Neurology won the 1st Prize for the "Innovative care" in

24 CONCLUSION Efficacy of this new music intervention on AD Easy to implement in a multidisciplinary programme Standardized and reproductible Multi-site studies 24

25 Thank you for your attention! 25